ASTRAZENECA PLC

AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of ethical (prescription) pharmaceuticals and the supply of healthcare services. It is one of world's leading pharmaceutical companies, with leadership in gastrointestinal, neuroscience, cardiovascular, respiratory, oncology and infection product sales. With the acquisition of Medimmune, AstraZeneca now has a significant position in biologicals and vaccines. AstraZeneca is listed in the Dow Jones Sustainability Index (Global) as well as the FTSE4Good Index. With approximately 67 000 employees, AstraZeneca's headquarters are in London.

Worldwide, AstraZeneca has 17 principal R&D centres, employing 13 000 people in 8 countries: Canada, China, France, India, Japan, Sweden, the UK and the USA. AstraZeneca has manufacturing activities in more than 20 countries. Scientists at AstraZeneca have discovered and developed many of today's leading prescription medicines. AstraZeneca, a global leader in the development of cancer therapies, is committed to continuing the fight against cancer, through early detection and awareness programmes and through
fundamental medical advances. AstraZeneca scientists are focused on developing a broad portfolio of anti-cancer products to extend and improve the quality of patients' lives.

Over the past 30 years, AstraZeneca has developed effective cancer medicines for patients with breast and prostate cancer.AstraZeneca produces Casodex (bicalutamide), the world's leading anti-androgen, Zoladex (goserelin acetate), the second largest-selling LHRH agonist in the world, Nolvadex, the first anti-oestrogen used in breast cancer, and the pure antioestrogen, Faslodex. We have also introduced a highly effective and well-tolerated third generation aromatase inhibitor, Arimidex, that has shown superior efficacy to the previous gold standard hormonal treatment for breast cancer, Tamoxifen. Current R&D focuses on developing treatment options across the prostate and breast cancer continuum, and specifically on novel biologically targeted approaches such as EGFR-TK inhibition, VEGFR-TK inhibition and vascular targeting.

AstraZeneca also has a major interest in diabetes and obesity, and stress-related disorders. In these conditions, AstraZeneca is looking for novel therapies that are a significant improvement on current treatments.

AstraZeneca, Mereside, Alderley Park, Macclesfield SK10 4TG, UK
http://www.astrazeneca.com