The phenotypic approach (1) – creation and characterisation of homologous knock-in mouse models

Dr Antonio Vidal-Puig

Summer School 11-14 July 2006
The Møller Centre, Storeys Way, Cambridge, UK

General Concept

General Strategy

Specific Objectives

1) To identify and functionally characterise new genes involved in control of energy balance and specifically:

a) in food intake
b) in energy expenditure
c) in fat deposition
d) in insulin sensitivity

2) To determine if the activity of candidate genes involved in energy balance identified in 1) are regulated by environmental factors: diet, cold and activity

3) To determine if gain/loss-of-function in candidate genes involved in energy balance identified in 1) 2) are important enough to cause:

a) Obesity
b) Diabetes
c) Dyslipidaemia
d) Hypertension

4) To further validate the role of genes identified in 1) 2) and 3) by complementation studies and therapeutic interventions to treat diseases associated with defects in energy balance (Obesity, Diabetes, Dyslipidaemia, Hypertension)

The opinions expressed in this paper are those of the speaker and do not necessarily reflect the views of the Society

Revised: 23-Aug-2006