22nd Joint Meeting of the British Endocrine Societies

Programme: Attended Posters

Mon 24 Mar | Tues 25 Mar | Wed 26 Mar | Attended Posters

Acrobat Icon Download Programme (pdf) (878kb)


Clinical case reports
Cytokines and growth factors
Diabetes, metabolism and cardiovascular
Endocrine tumours and neoplasia
Growth and development
Neuroendocrinology and behaviour
Novartis Awards Poster Session
Attended posters
Posters will be on display in Hall 2. Please note that even-numbered posters will be attended on Tuesday 25 March at 12.15 - 13.15 and odd-numbered posters will be attended on Wednesday 26 March at 12.15 - 13.15.


P1 Osteoblastic gene expression in cells of the adipocytic lineage
Ioannidou-Kadis S, Staley W, Byers RJ, Selby PL, Freemont AJ & Hoyland JA
P2 Effect of active acromegaly on parathormone circadian rhythm and phosphocalcium metabolism
White HD, Ahmad AM, Whittingham P, Peter R, Prabhakar K, Durham BH, Fraser WD & Vora JP
P3 Functional and association studies of calcium sensing receptor polymorphisms and mediators of calcium homeostasis
Harding B, Curley AJ, Christie PT, Bowl MR, Turner JJO, Barber M, Hampson G, Spector T & Thakker RV
P4 Hormone replacement treatment (HRT) increases circulating insulin-like growth factor binding protein-4 concentration
Heald AH, Kaushal K, Durrington P, Selby P & Gibson JM
P5 Determination of a correlation between release of beta c-terminal telopeptides and area of resorption by recombinant rankl-generated human osteoclasts
Chan BYY, Buckley KA, Dutton J, Gallagher JA & Fraser WD
P6 Parathyroid responsiveness to parathyroid hormone (1-34) infusion is altered in adult growth hormone deficiency following growth hormone replacement
Ahmad AM, Thomas J, White HD, Hopkins MT, Durham BH, Fraser WD & Vora JP
P7 Effects of thyroid hormone (T3) on fibroblast growth factor signalling in bone
Barnard JC, Williams AJ, Harvey CB & Williams GR
P8 IGF-I reverses dexamethasone induced growth retardation in mouse embryonic metatarsal cultures
Mushtaq T, Farquharson C, Seawright E & Ahmed SF
P9 Comparison of PTH concentration and phosphocalcium metabolism in treated adult growth hormone deficient patients with normal and reduced bone mineral density
White HD, Ahmad AM, Corlett P, Syed AA, Patwala A, Durham BH, Vora JP & Fraser WD
P10 The short stature homeobox containing gene (SHOX) inhibits alkaline phosphatase (ALP) production by C3H10T1/2 cells treated with retinoic acid (RA)
Blair JC, Sitara D, Milligan TP, Burrin JM & Clark AJL
P11 Effects of growth hormone replacement on parathyroid gland responsiveness to hypo- and hyper-calcaemic stimuli in adult growth hormone deficiency
Ahmad AM, Thomas J, White HD, Hopkins MT, Durham BH, Vora JP & Fraser WD
P12 Iranian national osteoporosis prevention plan-1 (inop-1): Preliminary report: relationship between vitamin D deficiency and markers of bone metabolism in urban 20-69 year-olds in Tehran, Iran
Pajouhi M, Larijani B, Hashemipour S, Adibi H, Shafaee A, Sedaghat M & Khalilifard A
P13 Hypophosphatemic rickets as a consequence of pregnancy: A case report
Jamieson A


Clinical case reports

P14 Combined pituitary hormone deficiency (CPHD) with adult-onset corticotropin deficiency but without evidence for PROP-1 or HESX1 mutations
Hammer F, Hahner S, Allolio B & Arlt W
P15 Rapid enlargement of thyroid neck swelling in two patients with thyroid dysfunction
Campbell HJ, Kapoor D, Thomas WEG & Jones TH
P16 Recurrent ovulation from an ovo-testis in 46XX/47XXY (mosaic) hermaphroditism: Serial high-resolution ultrasound characterisation
Barber TM, Ball SG & Elliott ST
P17 A novel DAX-1 gene mutation with adrenal hypoplasia congenita, differing degrees of hypogonadism and decreased bone mineral density
Abdalla T, Owen A, Curtis A & Wilton A
P18 Gender identity disorder in an Irish population
De Gascun C, Kelly J & O'Shea D
P19 Addisonian crisis in a patient with a progressive polyneuropathy
Lewandowski KC, Al-Din A, Spencer N, Andrew J, White C, Nagi DK & Jenkins RC
P20 Large parathyroid adenomas associated with vitamin D deficiency - quaternary hyperparathyroidism?
Brain HPS, Bano G, Kiely PDK, Sharma AK & Nussey SS
P21 The Pituitary Foundation: A national patient support group
Carson MN & Lightman SL
P22 A little hard to swallow: A rare cause of dysphagia in scleroderma
Wright KZ, Albon LM & Gittoes NJL
P23 Cushing's disease in adolescence
Dale JE, McGregor EJ, Johnson AP, Toogood AT, Shaw NJ, Anderson JM & Stewart PM
P24 Vanishing bone: Stabilisation of Gorham-Stout disease during antiresorptive therapy
Hammer F, Wesselmann U, Tunkel J, Arlt W & Allolio B
P25 An unusual presentation of hypopituitarism
Boyle JG, Deans KA & Hopkinson HE
P26 'My feet are killing me!' An unusual presentation of Cushing's syndrome
Albon LM, Rippin JD & Franklyn JA
P27 Delayed carbimazole induced agranulocytosis precipitating thyroid crisis
Srinivas U, Stanaway S, Worth R & Ewins D
P28 Fatal cardiac arrest in a woman with thyrotoxic crisis and sarcoidosis
Badman MK, Al-Izzi MS & Winocour PH
P29 Complimentary hyponatraemia
Browne DL & Krentz AJ
P30 Failure of metformin and pioglitazone in the treatment of congenital generalised lipodystrophy
Browne DL, Arundel F & Meeking DR
P31 Tumour metastases following laparoscopic resection of adrenal cortical carcinoma
Imtiaz KE, Nirodi GN, Wallis SC & Mughal MM
P32 Infantile methylmalonic aciduria caused by maternal pernicious anaemia
Wills CJ & Page RC
P33 80 years of hyperandrogenism
Evans PA, Wilkin TJ, Millward BA & Flanagan DE
P34 Developing an Endocrine Nurse Specialist post can improve service to patients with endocrine disease
Munday LJ, Wotherspoon F & Meeking DR
P35 Steroid responsive hypervitaminosis D due to sarcoid myopathy
Barnor Q, Haq M, Al-Memar A & Spring M
P36 Clear cell ovarian adenocarcinoma presenting with parathyroid hormone-related protein-dependent hypercalcaemia
Abdalla T, Rieck G, Leeson S, Wayte D, Owen A, Adams C & Wilton A
P37 A case of ectopic ACTH with severe opportunistic infection
Hatfield ECI, Pal S, Meeran K, Williams G & Todd JF
P38 Clinical features of phaeochromocytomas presenting as crises to an intensive care unit
Sibal L, Peaston R, Lennard T & Perros P
P39 Coexisting struma ovarii and Graves' disease
Teale EA & Peacey SR
P40 Testosterone implant therapy: An audit of patients' views
Sturrock AM, Brothwood T & Bouloux P-MG
P41 Incidental non-secretory pituitary adenoma in a case of ectopic ACTH induced Cushing's syndrome
Hay CJ, Adams JE, Teasdale GM & Wu FCW
P42 The use of intravenous etomidate infusion in the acute control of life-threatening hypercortisolaemia in a case of ACTH-dependent Cushing's syndrome
Hay CJ, Eddleston JM & Wu FCW
P43 Cortisol producing pheochromocytoma in pregnancy
Rangan S, Baskar V & Jackson MA
P44 Cyclical Cushing's syndrome associated with a pituitary gonadotrophinoma
Acharya S, Jones TH, Suliman M, Park C, Watson W, Abraham P & Bevan JS
P45 Tumour induced hypoglycaemia
Mc Quaid SE, Srinivasan S, Yeow TP, Rahman Y & Nolan JJ
P46 Acromegaly with hyperprolactinaemia - marked response to cabergoline therapy in a patient with a co-secreting tumour
Shah RV, McGowan BMC & Clements MR
P47 The UK National Acromegaly Database
Carson MN
P48 An unusual case of gynaecomastia
Koppada A, Nirodi GN & Imtiaz KE
P49 Pituitary carcinoma presenting as an aggressive non-functioning adenoma
Gallagher L, Gattameneni R, Holland JP & Davis JRE
P50 Hirsutism and subclinical Cushing's syndrome
Franke B, Foote J & Fisher R
P51 Adrenal rest tissue of the testes: A case report
O'Shea LA, Hackett C, Lennon F, Firth R & Kinsley BT
P52 Concurrence of primary hypothyroisism, epilepsy and benign intracranial hypertension in an adult
Dashora UK & Kennedy RL
P53 Vanishing sellar masses: Two case reports
Chillala J, Al Najjar Y & Issa BG
P54 Lymphocytic hypophysitis: A case report
Yeow TP, McQuaid SE, Srinivasan S, Rahman Y & Nolan JJ
P55 Growth hormone deficiency and pregnancy
Brackenridge AL, Breen L & Russell-Jones D
P56 An occult cause of hirsutism
O'Mullane NM, Watson A & Bannerjee B
P57 Young woman with galactorrhoea
Kashyap AS
P58 A case of Carney complex with unusual presentation
Shakoor SKA, Lalloo F & Davis JRE
P59 Calcitonin in nodular thyroid disease
Patel D & Johnston C
P60 Resolving adrenal insufficiency following haemorrhage into a pituitary adenoma
Goulden PA & Panahloo A
P61 Androgenisation during pregnancy - a case report
Darko DA, McClaverty C, Kyd P, Teoh TG & Robinson S
P62 Unexplained profound transient hypocalcaemia in a young male
Lewandowski K, Barth JH & Belchetz PE
P63 An unusual case of thyroid enlargement in pregnancy
Kos K, Warner D & West TET
P64 Persistent hypoglycaemia associated with neoplasia: A case of Doege-Potter syndrome
Ravichandran S, Imtiaz KE & Naqvi N
P65 Empty sella presenting as a syndrome of inappropriate antidiuretic hormone secretion
Helmy AFA


P66 Sheehan's syndrome and non-functioning pituitary adenoma - a comparison of clinical characteristics and response to growth hormone replacement
Goth MI, Auernhammer C, Colak R, Gomez JM, Molvalilar S & Kelestimur F
P67 Prostaglandins modulate the renal actions of antidiuretic hormone in the Peking duck
Gray DA
P68 Do plasma osmolality methods meet clinical requirements?
Twomey PJ, Don-Wauchope AC & McCullough DA
P69 Analysis of human renal chloride channel (hCLC-5) mutations based on a three-dimensional model, suggests a structural-functional relationship
Wu F, Roche P, Christie PT, Loh NY, Reed AAC, Esnouf RM & Thakker RV

Cytokines and growth factors

P70 Growth hormone (GH) insensitivity due to a mutation in the cytoplasmic domain of the GH receptor distal to Box 1
Milward AD, Metherell L, Maamra M, Wilkinson IR, Camacho-Hubner C, Savage MO, Ross RJM, Clark AJL & Webb SM
P71 A growth hormone receptor (GHR) - glycophosphatidylinositol (GPI) chimera acts as a receptor antagonist
Gavalas NG, Pradhananga SL, Beghadi C, Maamra M, Zarkesh-Esfahani H, Sayers J, Artymiuk P, Reymond C & Ross RJM
P72 Relationships between IL-6 levels and anthropometric, metabolic and hormonal parameters in women with PCOS and the effect of treatment with metformin
Tsilchorozidou T, Mohamed-Ali V & Conway GS
P73 Increased angiogenesis but not lymphangiogenesis in parathyroid proliferative lesions: A possible role for FGF-2
Garcia de la Torre N, Wass JAH, Buley I, Jackson DG & Turner HE
P74 Leptin enhances expression of CD11b by human neutrophils through TNF-a
Zarkesh-Esfahani H, Pockley AG, Hellewell PG, Weetman AP & Ross RJM
P75 Overexpression of somatostatin receptors 1 and 5, and VEGF and its receptors FLK and FLT in laryngeal carcinoma: Potential targets for anti-tumoral therapy?
Condon LT, Rogers MJC, Macdonald AW, Stafford ND & Atkin SL
P76 Development of a bioassay for leptin agonists and antagonists
Fazeli M, Zarkesh-Esfahani H, Maamra M, Justice S & Ross RJM
P77 Serum concentrations of interleukin-18 and tumour necrosis factor alpha are associated to the features of the metabolic syndrome X in adults
Olusi SO
P78 Concentrations of serum Interleukin-18, tumour necrosis factor alpha and plasma malondialdehyde are associated with body mass index in healthy adults
Olusi SO

Diabetes, metabolism and cardiovascular

P79 Identification of the gene causing familial juvenile hyperuricaemic (Gouty) nephropathy
Stacey JM, Turner JJO, Harding B, Kotanko P, Lhotta K, Puig JG, Roberts I, Torres RJ & Thakker RV
P80 Influence of the Y chromosome on inter-individual variation in cholesterol serum levels of young men
Charchar FJ, Tomaszewski M, Lacka B, Zakrzewski J, Zukowska-Szczechowska E, Grzeszczak W & Dominiczak AF
P81 Effects of the 11beta hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in human obesity
Sandeep TC, Andrew R, Homer NZM & Walker BR
P82 Effect of grape procyanidins on proliferation and apoptosis of pancreas beta cells
Zhong Jinyi
P83 Testosterone is a dilator of resistance arteries in men with congestive heart failure
Malkin CJ, Pugh PJ, Jones RD, Jones TH & Channer KS
P84 Orlistat use outside of clinical trials: The Irish experience
Tuthill A, Kelly R, Ryan Y & O'Shea D
P85 Adrenomedullin and proadrenomedullin N-terminal 20 peptide have opposing effects on CRLR gene expression in human adrenal cells
Vakharia K & Hinson JP
P86 Autosomal dominant neurohypophyseal diabetes insipidus associated with a glutamine47 deletion
Alcocer L, Boxer M, Connell JM & Ahmed SF
P87 Circulating IGFBP-3 concentration is independently associated with insulin resistance and BMI
Heald AH, Anderson S, Cruickshank JK & Gibson JM
P88 Mechanisms of splicing inhibition in apolipoprotein B exon 26 (ApoB ex26)
Khoo B, Akker SA & Chew SL
P89 OGIS: An index of insulin sensitivity in a clinical setting
Rahman Y, McQuaid S, Yeow TP & Nolan J
P90 Paradoxical correlation between serum zinc and neutrophil respiratory burst in the resting and stimulated states in type 2 diabetic patients with foot ulcers
Larijani B, Mossafa N, Shooshtarizadeh P, Nourai M, Vassigh AR, Javadi E & Shafaee AR
P91 Baseline clinical characteristics and response to growth hormone replacement therapy in adults with isolated growth hormone deficiency in comparison with multiple pituitary hormone deficiencies
Waterhouse M, Laureiro R, Walker D, Besser GM & Monson JP
P92 Cardiovascular risk factors in obese children and their association with insulin resistance
Sabin MA, Crowne EC & Shield JPH
P93 Reduced insulin sensitivity in healthy glucose tolerant first degree relatives of patients with type 2 diabetes mellitus
Raskauskiene D
P94 Glycaemic control, weight change and treatment: Examining the relationship in type 2 diabetes
Tuthill A, Curran S, McKenna M, O'Shea D & McKenna TJ
P95 Subcutaneous and visceral preadipocytes from pre-pubertal children show site-specific differences in insulin action
Grohmann MJ, Sabin MA, Holly JMP, Shield JPH, Crowne EC & Stewart CEH
P96 The effect of menopausal status on the biological variation of insulin resistance
Jayagopal V, Kilpatrick ES, Jennings PE, Hepburn DA & Atkin SL
P97 Altered insulin sensitivity and secretion in Sotos syndrome
Nag S, Bennett SMA, Gerrard J, Walker M & Ball S
P98 The predictive factors for gestational diabetes mellitus and postpartum diabetes mellitus
Larijani B, Hossein-nezhad A, Pajouhi M & Bastanhagh MH
P99 Hypertension in diabetics and non-diabetics; degree of blood pressure control and antihypertensive agents
Akbar DH & Algamdi AA
P100 Treatment of coronary disease and effects on endogenous testosterone levels
Malkin CJ, Pugh PJ, Jones TH & Channer KS
P101 Octreotide LAR - a patient and nurse perspective
Thornton-Jones VA, Turner HE & Wass JAH
P102 Early onset type 2 diabetes in an Irish population
McQuaid SE, Rahman Y, Yeow TP, O'Gorman DJ, Gasparro D, Yousif O & Nolan JJ
P103 A 5 year retrospective analysis of diabetes ketoacidosis
Yeow TP, McQuaid SE, Rahman Y & Nolan JJ
P104 Type 2 diabetes in Alstrom syndrome: Targeting insulin resistance with a thiazolidinedione
Nag S, Kelly WF, Walker M & Connolly V
P105 Polycystic ovary syndrome (PCOS) in Sri Lankans
Wijeyaratne CN, Balen AH, Barth JH & Belchetz PE
P106 Metformin: Its effect on weight loss in obese patients with or without polycystic ovary syndrome
Mukhtar RY, Pettit A & Robinson AM
P107 Mass screening for diabetes: New horizon with computer aided diagnosis system?
Rahman Y, McQuaid S, Yeow TP, Knape T, Gargan M, Wade V, Nolan J & Grimson J
P108 Hypopituitarism presenting as hypoglycaemia in type 2 diabetes
Newey P & Jamieson A
P109 Blood stream infections are common in admitted diabetics
Akbar DH
P110 Timing of insulin administration amongst diabetic patients
Mountford CG, McCulloch AJ & Nag S
P111 Abnormal immunoglobulin A and D levels in children with type 1 diabetes
Haroun M & Brzeski H
P112 The effect of blood glucose in non-diabetic pregnant women on their infants' weight
Vasegh F & Shahri P
P113 Unusual causes for hypokalaemia in diabetics
Solomon AM & Cunnah DTE

Endocrine tumours and neoplasia

P114 Familial isolated primary hyperparathyroidism due to germline multiple endocrine neoplasia Type 1 (MEN1) mutations
Turner JJO, Pannett AAJ, Kennedy AM, Forbes SA, Cavaco BM, Bassett JHD, Cianferotti L, Harding B, Shine B, Flinter F, Maidment CGH, Trembath R & Thakker RV
P115 Prostate and ovarian cancer cell responses to treatment with 2-substituted oestrogen sulphamates in vitro
Day JM, Newman SP, Comninos A, Solomon C, Purohit A, Leese MP, Potter BVL & Reed MJ
P116 Dysregulated extra-renal synthesis of 1,25-dihydroxyvitamin D3: A novel cause of hypercalcemia associated with ovarian dysgerminomas
Evans KN, Zehnder D, Kilby MD, Taylor H & Hewison M
P117 Parathyroid tumours harbour parafibromin somatic mutations, consistent with the Knudson 'two-hit' hypothesis
Cavaco BM, Bradley KJ & Thakker RV
P118 Genetic abnormalities in carcinoid tumours
Leotlela PD, Turner JJO, Holtgreve-Grez H, Jauch A & Thakker RV
P119 Hyperparathyroidism-jaw tumour syndrome (HPT-JT) in Romany families from Portugal is due to a founder mutation of parafibromin
Cavaco BM, Guerra L, Carvalho D, Bradley KJ, Harding B, Kennedy AM, Santos MA, Sobrinho LG, Thakker RV & Leite V
P120 Clinical and biochemical prognostic indicators at diagnosis in 117 midgut carcinoid tumours
Turner GB, Johnston BT, McCance DR, Watson RGP, Buchanan KD & Ardill JES
P121 Differential modulation of key steroidogenic enzymes through orphan nuclear transcriptional regulation may control the diverse production of cortisol and adrenal androgens
Kelly SN, Mason JI, Mc Kenna TJ & Young LS
P122 IL1 alpha, IL6 and MMP13 are required for invasion by the human pituitary cell line HP75
Borg SA, Royds JA & Jones TH
P123 Preoperative determination of serum thyroglobulin may identify patients with differentiated thyroid cancer who might recur without increased thyroglobulin
Gibelli B, Tradati N, Tredici P, De Cicco C, Bodei L, Sandri MT & Chiesa F
P124 Acromegaly: A study of epidemiological characteristics and treatment outcomes
Brown CK, Sampson MJ, Greenwood RH, Heyburn PJ & Temple RC
P125 Dysregulation of the vitamin D axis in colorectal cancer
Ogunkolade BW, Kelly PJ, Khalaf S, Fairclough PD, Bustin SA & Jenkins PJ
P126 Outcomes in acromegaly: A retrospective study of 419 patients from the West Midlands region of the United Kingdom
Ayuk J, Clayton RN, Sheppard MC, Stewart PM & Bates AS
P127 Proliferative regulation of human breast cancer cells by dietary phytoestrogens: Mechanisms of estrogen receptor-mediated signalling
Limer JL & Speirs V
P128 CYP27b and CYP24 expression combine to determine 1,25 dihydroxyvitamin D3 insensitivity in breast cancer cells
Townsend K, Banwell CM, Stewart PM, Hewison M & Campbell MJ
P129 Stable iodide and radioiodide transport in extrathyroidal tissues
Clarke C, Brennan CG, Rodgers K, Dwyer RM & Smyth PPA
P130 Identification of the ACTH receptor in the human pituitary and its loss of expression in pituitary adenomas
Morris DG, Kola B, Borboli N, Kaltsas GA, Gueorguiev M, Jones TH, Baldeweg S, Powell M, Korbonits M & Grossman AB
P131 The presence of ghrelin protein in the rat hypothalamus and the effect of ghrelin on corticotrophin releasing hormone (CRH) and arginine vasopressin (AVP) release from rat hypothalamic explants pituitary tumours
Mozid AM, Tringali G, Forsling ML, Hendricks M, Ajodha S, Edwards R, Navarra P, Grossman AB & Korbonits M
P132 Pituitary tumor transforming gene upregulates its binding factor PBF in vitro
Stratford AL, Khanim F, Boelaert K, Gittoes NJL, Franklyn JA & McCabe CJ
P133 Insulin-like growth factor binding protein-3 (IGFBP-3) expression in the caecum and rectum of patients with, and without, acromegaly
Khalaf S, Kelly P, Ogunkolade BW, Fairclough PD, Bustin SA & Jenkins PJ
P134 Expression of IGF-I in normal and malignant breast tissue and its association with tumour size
Laban CA, McCarthy K, Ogunkolade W, Bustin SA, Carpenter R & Jenkins PJ
P135 Expression of IGFBP-3 mRNA in breast cancer in relation to clinical phenotype
McCarthy K, Ogunkolade W, Laban CA, Khalaf S, Bustin SA, Carpenter R & Jenkins PJ
P136 Methylation status and iodide uptake
Brennan CG, Dwyer RM, Clarke C & Smyth PPA
P137 Prolactinoma volume and serum prolactin level: Evidence for the 'silent lactotroph' tumour
Levy MJ, Thompson P, Powell M & Ahlquist JA
P138 Lipocortin-1 expression within normal and abnormal endometrium
Bedford KJ, Richmond I, Taylor AD & Atkin SL
P139 Co-regulators SRC-1 and SMRT interact with ER-alpha and ER-beta in human breast cancer
Fleming FJ, Hill ADK, Mc Dermott EW, O'Higgins N & Young LS
P140 Pituitary irradiation for recurrent steroid-responsive hypophysitis in three patients
Coyle F, Beaney R, Miell J, Bullock P, Al-Sarraj S, McGregor AM & Aylwin SJB
P141 Abnormal expression of 11beta-hydroxysteroid dehydrogenase 2 in primary cultures of human pituitary adenomas
Rabbitt EH, Bujalska IJ, Stewart PM, Hewison M & Gittoes NJL
P142 Cell cycle dysregulation in parathyroid adenoma and carcinoma
Valentine G, Jordan S, Lu X, Lowe DG, Hirace R, Korbonits M & Grossman AB
P143 Transcriptional regulation by PEA3 in human breast cancer
Myers E, Buggy Y, Hill ADK, Duffy MJ, O'Higgins N & Young LS
P144 Metaiodobenzylguanidine scintigraghy (MIBG) and familial screening are not useful in phaeochromocytoma
Gardner SG, Amin R, Atkinson CJ, Turner HE & Wass JAH
P145 Molecular genetic diagnosis for disorders of calcium metabolism
Cranston T, Huson SM, Seller A & Thakker RV
P146 Expression of somatostatin receptors in proliferating and quiescent endothelial cells
Adams RL, Adams IP & Atkin SL
P147 Abstract withdrawn
P148 A TSH response to a single octreotide test dose predicts a long term response to somatostatin analogue therapy in patients with a TSH-secreting pituitary adenoma
Bingham E, Alcock CR, Miell J, Harris PE, McGregor AM & Aylwin SJB
P149 Usefulness of growth hormone response to a test dose of subcutaneous octreotide in predicting longer-term response to the drug. Poor responses predict the need for adjuvant therapy to achieve 'safe' growth hormone levels
Lindsay JR, McConnell EM, Hunter SJ, McCance DR, Sheridan B & Atkinson AB
P150 Expression of vascular endothelial growth factor and its receptors in human anterior pituitary adenomas
Adams IP, Henderson R, Green VL, Foy PM, Macfarlane I & Atkin SL
P151 IGF-I inhibits COX-2 function in primary colonic biopsies of patients with acromegaly
Kelly PA, Vojnovic I, Fairclough PD, Warner T, Bustin SA & Jenkins PJ
P152 Can petrosal sinus ACTH and prolactin responses to CRH help localize the tumour in Cushing's disease due to pituitary microadenomas?
Daousi C, Nixon T, Hayden C, Foy PM, Diver M & MacFarlane IA
P153 A rapid method for analysing serum pro-insulin-like growth factor-II (pro-IGF-II) in patients with non-islet cell tumour hypoglycaemia (NICTH)
Miraki-Moud F, Monson JP, Besser GM, Grossman AB & Camacho-Hübner C
P154 A new role for the endocrine nurse within a multidisciplinary approach to neuroendocrine tumours
Stewart SE
P155 Transsphenoidal surgery for acromegaly in Wales: Results based on stringent criteria of remission
De P, Rees DA, Davies N, John R, Neal J, Mills RG, Vafidis J, Davies JS & Scanlon MF
P156 Carney complex type 1 gene (PRKAR1A) expression and sequence analysis in sporadic somatotroph and other pituitary tumours
Borboli N, Kaltsas GA, Kola B, Gueorguiev M, Czirják S, Kirschner L, Stratakis SA, Korbonits M & Grossman AB
P157 Elevated alpha fetoprotein levels in association with a metastatic neuroendocrine tumour
Hanna GG, Cross M, Ardill J, Johnston BT & McCance DR
P158 Retrospective audit of care of patients undergoing pituitary surgery in Plymouth
Wotherspoon F, Dyer RG & Pobereskin L
P159 Lymphocytic adenohypophysitis occurring simultaneously with an ACTH secreting adenoma
Cuthbertson DJR, Carey P, Ritchie D, Rossi M & Vora J
P160 Double trouble: Dual pathology and false positive as well as false negative imaging in a man with phaeochromocytoma and hypogonadism
Jacob K, Ganesaratnam S & Winocour P

Growth and development

P161 Testosterone enhances the effect of growth hormone (GH) to increase IGF-I but exerts an anabolic effect that is independent of GH action
Gibney J, Wolthers T, Males M, Smythe G, Umpleby AM & Ho KKY
P162 GATA3 missense mutation disrupts interaction with friend of GATA 2 (FOG2) and causes the hypoparathyroidism, deafness and renal dysplasia (HDR) syndrome
Nesbit MA, Bowl MR, Ali A & Thakker RV
P163 Identification of GATA3 zinc finger 1 residues that are important for interactions with friend of GATA 2 (FOG2)
Ali A, Nesbit MA & Thakker RV
P164 A potential role for human securin/PTTG in the developing human fetal brain
Boelaert K, McCabe CJ, Tannahill LA, Bulmer JN, Chan SY, Gittoes NJ, Sheppard MC, Kilby MD & Franklyn JA
P165 A unique sequence element that silences the growth hormone receptor (GHR) pseudoexon
Akker SA, Khoo B, Metherell LA, Clark AJL & Chew SL
P166 A novel mutation within the conserved EH-1 domain of HESX1 causes evolving CPHD due to the loss of interaction with the co-repressor TLE1
Woods KS, Carvalho L, Zamparini AL, Stifani S, Marcal N, Turton JPG, Mendonca BB, Brickman JM, Arnhold IJ & Dattani MT
P167 The use of a specific questionnaire to assess quality of life in growth hormone deficient adults
Sathiavageeswaran M, Bisp K & Wass JAH
P168 Differential regulation of the ghrelin promoter in WRL68 and HEK293 cells
Macartney DP, Hughes BA, Stewart PM, Sheppard MC & Toogood AA
P169 Expression and distribution of the prolactin-receptor in healthy, fibrotic and cirrhotic liver in rats and humans
Kloehn S, Simon-Holtorf J, Bachmann J & Mönig H
P170 Regulation of Wolffian duct development in patients with complete androgen insensitivity syndrome
Hannema SE, Martin H & Hughes IA
P171 The effect of chronic administration of recombinant (human) leptin on leptin and uncoupling protein (UCP) 2 mRNA in neonatal pigs
Litten JC, Perkins KS, Bell M & Clarke L
P172 Adults with partial growth hormone (GH) deficiency have an adverse body composition
Murray RD, Adams JE & Shalet SM
P173 The effect of chronic administration of recombinant (human) leptin on the growth performance of neonatal pigs
Litten JC, Bell M, Perkins KS & Clarke L
P174 The effect of maternal dietary supplementation during late gestation on the growth performance of intra-uterine growth restricted (IUGR) pigs
Perkins KS, Litten JC, Corson AM, Laws J & Clarke L
P175 The use of combined GHRH and arginine test in the diagnosis of growth hormone deficiency in successfully treated acromegalics
Sathiavageeswaran M, Bisp K & Wass JAH
P176 Cessation of growth hormone (GH) results in loss of lean body mass and reduced accrual of bone mass in adolescents with severe GH deficiency - 2 year follow up
Carroll PV, Drake WM, Maher KT, Metcalfe K, Savage MO, Dunger DB, Shaw NJ, Camacho-Hubner C & Monson JP

Neuroendocrinology and behaviour

P177 Galanin-like peptide interactions with leptin and GnRH
Seth A, Stanley SA, Ghatei MA & Bloom SR
P178 Insulin sensitivity improves in patients with acromegaly converted from depot octreotide (Sandostatin LAR) to pegvisomant
Drake WM, Rowles SV, Roberts ME, Fode FK, Besser GM, Monson JP & Trainer PJ
P179 Intracerebroventricular ghrelin injection acutely stimulates food intake and inhibits luteinising hormone secretion in sheep
Harrison JL, Findlay PA, Miller DW & Adam CL
P180 Intra-hypothalamic gene transfer of cocaine- and amphetamine-regulated transcript results in increased food intake and weight gain
Ward HL, Gardiner JV, Smith KL, Kong WM, Martin NM, Small CJ, Ghatei MA & Bloom SR
P181 A randomised double-blind cross-over study of GH treatment in patients over 60 years
Mah PM, Walters SJ, Newell-Price JD, Webster J, Doane A, Ibbotson V, Hosker JP, Jones TH, Ho KK, Eastell R & Ross RJ
P182 Hypopituitarism following cranial irradiation for non-pituitary brain tumours
Agha A, O'Connor S, Rogers B & Thompson CJ
P183 Serum leptin, insulin, IGF- levels and body composition in partially and fully recovered patients with anorexia nervosa
Djurovic M, Petakov M, Damjanovic S, Pekic S, Glisic B, Miljic D, Doknic M, Dieguez C, Casanueva F & Popovic V
P184 Differential effects of the route of testosterone administration on GH sensitivity and bone mineral density in hypopituitarism
Brooke AM, Carroll PV, Walker D, Besser GM & Monson JP
P185 Abnormal endocrine tests in chronic pain require investigation and are not the result of opioid analgesia
Merza Z, Edwards N, Walters S, Newell-Price J & Ross RJM
P186 Effect of the novel somatostatin ligand, SOM230, on rat and human anterior pituitary hormone secretion
Murray RD, Kim K, Ren SG, Weckbecker G, Bruns C & Melmed S
P187 Pituitary apoplexy: A review of presentation, management and outcome
Vaidya B, Sibal L, Kane P, Brady N, Connolly V, James RA & Kelly W
P188 Treating hyperprolactinaemia: Where to draw the line?
Qureshi AI, Bano G & Nussey SS
P189 Treatment outcome in acromegaly: Results from the Beaumont Hospital pituitary database
Agha A, Ng S, Rogers B, Philips J & Thompson CJ
P190 Single centre audit of surgical outcome in acromegaly
Baldeweg SE, Conway GS, Powell M & Vanderpump M
P191 Problematic development of an immunometric assay for cocaine and amphetamine regulated transcript (CART) (55-102) peptide fragment
Darch SJ, Chapman RS, Murphy KG & Bloom SR
P192 Audit of quality of life in individuals who have undergone treatment for pituitary tumours over the past ten years at a single neurosurgical centre
Fowler HL, Ghosh S, Buckler H & Heald AH


P193 Maternal and neonatal outcomes after conception during cabergoline therapy for hyperprolactinaemia
Booth SA, Philip S, Middleton M, Park CM, Abraham P & Bevan JS
P194 Insulin sensitivity in polycystic ovary syndrome -influence of peroral versus transdermal estrogen treatment
Vrbikova J, Stanicka S, Dvorakova K, Hill M, Vondra K & Starka L
P195 Oxygen tension regulates placental 11beta-hydroxysteroid dehydrogenase type 2
Driver PM, Hewison M, Kilby MD & Stewart PM
P196 Clinical features of patients with macroprolactinaemia
Teoh WL, Strachan M, Don-Wauchope A, Beckett GJ, Stoddart M & Seth J
P197 Hypoxia influences steroid and nitric oxide production in swine granulosa cells
Bianco F, Grasselli F, Basini G, Tirelli M, Bussolati S, Cavalli V & Tamanini C
P198 Effect of aroclor 1242 (PCB) on the reproductive function of adult male rhesus monkey (Macaca mulatta)
Ahmad MM, Ahmad SU & Tariq S
P199 Treatment of hypogonadotropic hypogonadism in women with neuroendocrine disorders
Ilovaiskaia IA, Pischulin A & Marova EI
P200 Biological variation of free androgen index and bioavailable testosterone in PCOS: Implications for estimation of hyperandrogenaemia
Jayagopal V, Diver MJ, Kilpatrick ES, Jennings PE & Atkin SL
P201 Screening for iron deficiency and anaemia in adults with Turner syndrome
Ostberg JE & Conway GS
P202 Complications of testosterone replacement in men with primary and secondary hypogonadism
Meston N, Turner HE & Wass JAH
P203 A more rigorous laboratory definition of macroprolactinaemia with clinical significance
Smith TP, Gibney J, Kavanagh L, Dickinson A & McKenna TJ
P204 The effect of insulin-like growth factor-I (IGF-I) on initiation of human follicle growth in vitro
Stubbs S, Zachery-Jennings C, Margara R, Trew GM, Franks S & Hardy K
P205 Effects of CAG repeat expansion of the androgen receptor and its truncation on neural and non-neural cells
Wong JM, Zajac JD, Warne GL & Greenland KJ
P206 Sexual dimorphism in fetal testosterone output in the silver fox
Osadchuk LV
P207 Polycystic ovary syndrome (PCOS) has a significant negative impact on health-related quality of life (HRQoL)
Coffey S, Bano G & Mason H
P208 Pharmacokinetics and tolerability of a new bioadhesive buccal testosterone tablet in testosterone deficient men
Ross RJM, Jabbar A, Jones H, Roberts B, Dunkley K, Long A, Levine H & Cullen DR
P209 Immunopurification of gonadotrophin surge-attenuating factor (GnSAF) bioactivity
Sorsa-Leslie T, Harris WJ, Mason HD & Fowler PA
P210 Comparison between azoospermic responders and oligozoospermic non-responders to sex steroidal contraception: A pharmacogenetics study examining the androgen receptor, CYP17, LHbeta and 5alpha-reductase-2 genes
Oxynos C, Thakker N, Hewitt C, Southern L, Anderson RA, Huhtaniemi IT, Yong EL & Wu FCW
P211 1,25-Dihyroxyvitamin D3 has a direct effect on steroid production from human theca cells
Brain HPS, Bano G, Brincat M, Galea R, Pellatt LJ, Nussey SS & Mason HD
P212 Evidence for the use of metformin in women with polycystic ovary syndrome
Sattar N, Harborne L, Lyall H, Norman J & Fleming R
P213 Testosterone pellet implants - an acceptable mode of androgen replacement
Swinburne J, Ward E & Belchetz PE
P214 Investigating germ cell development and differentiation in the human fetal testis
Gaskell TL, Robinson LL, Anderson RA & Saunders PTK


P215 11Beta-hydroxysteroid dehydrogenase in human fibroblasts: Expression and regulation depends on tissue of origin
Moore J, Filer A, Buckley CD, Stewart PM, Hewison M & Cooper MS
P216 Adipocyte size increases with BMI, but is unrelated to 11 beta-hydroxysteroid dehydrogenase type 1 expression
Tomlinson JW, Bujalska I, Collard M & Stewart PM
P217 Interactions between 11beta-hydroxysteroid dehydrogenase type 1 and 5beta-reductase
Livingstone DEW, Reidy L, Drake AJ, Paterson JM, Walker BR & Andrew R
P218 Studies on functional activity of human ERbeta wild type and variant isoforms
Sierens J, Scobie GA, Wilson JA & Saunders PTK
P219 Mutagenesis studies on recombinant human 11beta-hydroxysteroid dehydrogenase type 1
Walker EA, Hughes SV, Ride JP, Hewison M & Stewart PM
P220 The relationalship of on-admission plasma cortisol to outcome in critical illness: A longitudinal prospective study
Jaiswal V, Baudouin SV & Ball SG
P221 CYP7B catalyses the 7alpha-hydroxylation of dehydroepiandrosterone in human prostate
Martin CP, Ross M, Seckl JR & Habib F
P222 In vitro expression of human aldosterone synthase and 11-beta hydroxylase
Inglis GC, Davies E, Fraser R & Connell JMC
P223 Excretion of the urinary metabolite of deoxycortisol is heritable and influenced by polymorphic variation at the CYP11B2 (aldosterone synthase) locus
Myosi B, Keavney B, Watkins H, Davies E, Ingram M, Fraser R & Connell J
P224 Differential regulation of vitamin D receptor and its ligand in human dendritic cells: A paracrine mechanism for regulation of antigen presentation
Freeman L, Evans K, Hughes SV, Moss P, Chakraverty R & Hewison M
P225 High prevalence of low testosterone levels in men with coronary heart disease and an association with hypertension and obesity - the South Yorkshire study
Pugh PJ, Morris PD, Hall J, Malkin CJ, Asif S, Jones RD, Channer KS & Jones TH
P226 Identification of glucocorticoid target genes in human subcutaneous and omental adipose tissue using microarray analysis
Bujalska IJ, Montague CT, Smith DM & Stewart PM
P227 The 5' untranslated region of the rat glucocorticoid receptor contains elements important for cell-specfic promoter activity and glucocorticoid regulation
Munn HL, Lyons V, McCormick JE, Seckl JR & Chapman KE
P228 Activation of the hypothalamic-pituitary-adrenal axis in adult women with low birthweight
Reynolds RM, Walker BR, Syddall HE, Andrew R, Wood PJ & Phillips DIW
P229 Regulation of aldosterone synthase (CYP11B2) gene expression in the rat adrenal gland and central nervous system by sodium and angiotensin II
Ye P, Kenyon CJ, MacKenzie SM, Fraser R, Connell JMC & Davies E
P230 Beneficial affects of regular exercise: Is it all in the hormones?
Andrews RC & Wood P
P231 Development of a mouse hypertension model induced by aldosterone excess
Marshall E, Speirs HJL, Coan SK, Mullins JJ, Kenyon CJ & Brown RW
P232 Urinary 18-hydroxycortisol: Diagnostic utility of three methods compared
Reynolds RM, Sandhu K, Shakerdi LA, Wallace AM, Wood PJ & Walker BR
P233 In vitro
Shakerdi LA, Friel EC, Davies E, Connell JMC, Wallace AM & Fraser R
P234 Aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) gene expression in the normal and failing rat heart
Millar CA, Ye P, Gray GA, Wallace AF, MacKenzie SM, Fraser R, Connell JMC & Davies E
P235 Cardiovascular risk assessment in bodybuilders abusing anabolic steroids
Lane HA, Grace F, Lewis J, Morris K, Thomas AW, Scanlon MF, Davies JS & Cockroft J
P236 Regulation of the human 11beta-hydroxysteroid dehydrogenase gene by glucocorticoids
Bedendo O, Bujalska IJ, Draper N, Walker EA, Hewison M, Mantero F & Stewart PM
P237 Cortisol metabolite excretion and 11-hydroxysteroid dehydrogenase type 1 activity are strongly heritable in man
Myosi B, Watkins H, Keavney B, Ingram M, Fraser R, Davies E & Connell J
P238 Contrasting acute and chronic changes in glucocorticoid action during high fat feeding in rats
Drake AJ, Livingstone DEW, Reidy L, Andrew R, Morton NM, Seckl JR & Walker BR
P239 Effect of dietary sodium manipulation on aldosterone synthase (CYP11B2) gene expression in the rat cardiovascular system
Ye P, Kenyon CJ, MacKenzie SM, Fraser R, Connell JMC & Davies E
P240 Is the cortisol day curve a useful tool?
Evans PA, Wilkin TJ, Jeffery J, Williams R & Flanagan DE
P241 Urinary steroid hormone metabolites in patients with porphyrias
Christakoudi S, Deacon AC, Peters TJ & Taylor NF
P242 Functional analysis of the N/C interactions in the AR
Stol K, Martin H, Jaaskelainen J & Hughes IA
P243 Insulin sensitivity and hypoglycaemic susceptibility in children with endocrinopathies reflects the underlying hormone deficiency and treatment regimen
Johnstone HC, Bartlett K & Cheetham TD
P244 Bilateral massive adrenal enlargement in a poorly treated adult patient with salt losing congenital adrenal hyperplasia
Nagi DK, Ajjan R, Andrew J, Walker P, Ismail A & Jenkins R
P245 Audit of adrenal vein sampling for primary aldosteronism
Sibal L, Raza A, Leen B & Kelly W
P246 Testosterone reduces free radical release from human monocytes
Lane HA, Smith J, Rathbone N, Morris K, Thomas A, Scanlon MF & Davies JS
P247 Can random urine samples substitute for 24 hour collections for steroid profiling?
Jerjes WK & Taylor NF
P248 A non-invasive test of mild glucocorticoid resistance
Jerjes WK, Wood PJ & Taylor NF
P249 Mutations in the HSD11B2 gene causing AME in the Oman population
Atterbury AJ, Draper N, Lavery GG, Walker EA, DeSilva V, Taylor NF, Hala S, Rajendra N, Bappal B & Stewart PM
P250 Isolated ACTH deficiency precipitated by silent thyroiditis presenting as acute metabolic acidosis
Ajjan R, Andrew J, Spilker C, Ismail A & Nagi DK
P251 Macroprolactinoma and pituitary dependent Cushing's syndrome: An unusual combination with response to dopamine agonist therapy
Ajjan R, Andrew J, Jenkins R, Walker P, Ismail A & Nagi DK
P252 The influence of anticoagulant preservatives, time and posture in renin measurements and estimation of aldosterone to renin ratio (ARR)
Al-Hashmi KM, Morton JJ, Elliott HL & Connell JM
P253 Assessment of antiandrogenic activity in a range of environmental contaminants
Jones ER, Martin H, Acerini CL & Hughes IA


P254 Thyroid hormone receptor (TR) activity is modulated by TRdeltabeta3 in a cell- response element- and TR isoform-specific manner
Harvey CB & Williams GR
P255 Preliminary evidence for genetic heterogeneity in the autoimmune polyendocrinopathy and enteropathy syndrome (IPEX)
Owen CJ, Jennings CE, Imrie H, Lachaux A, Bridges NA, Cheetham TD & Pearce SHS
P256 The type II and III iodothyronine deiodinase enzymes are expressed in differentiating growth plate chondrocytes
Robson H, Shalet SM & Williams GR
P257 Does iodide modulate the biological outcome of activating thyrotropin receptor mutations?
Al-Khafaji F & Ludgate M
P258 The W546X mutation of the thyrotropin receptor gene: Potential major contributor to thyroid dysfunction in a caucasian population
Jordan NJ, Willliams N, Gregory JW, Evans C, Owen M & Ludgate M
P259 The expression of apoptotic genes in autoimmune thyroid diseases
Waheed S, Hammond LJ, Biro PA & Mirakian R
P260 Iodide effects on iodide transport and organification in human thyroid cells in vitro
Eggo MC & Black EG
P261 The epidemiology of thyroid cancer in Scotland, 1960-1999
Weir J, Brewster DH & Strachan MWJ
P262 The controlled antenatal thyroid screening study (CATS) - first observations
Lazarus JH, Wald NJ, Angele C, George LM, Seed PT, Taylor IL & Parkes AB
P263 Cardiac autonomic function in hyperthyroidism
Osman F, Daykin J, Chowdhary S, Sheppard MC, Gammage MD & Franklyn JA
P264 Is the thyroglobulin gene a susceptibility locus for autoimmune thyroid disease in the UK?
Collins JE, Heward JM, Franklyn JA & Gough SCL
P265 Assessment of UK Caucasian allele frequencies of known TNF-alpha polymorphisms and their association with Graves' disease
Simmonds MJ, Nithiyananthan R, Heward JM, Franklyn JA & Gough SCL
P266 Psychological well-being in patients on 'adequate' doses of L-thyroxine
Saravanan P, Chau F, Roberts N, Vedhara K, Greenwood R & Dayan CM
P267 Does HLA-DRB1-DQA1-DQB1 genotype contribute to chronic autoimmune thyroiditis development in adult patients with diabetes mellitus type 1?
Dvorakova K, Vondra K, Bendukidze N, Bendlova B, Ivaskova E, Sterzl I, Vrbikova J & Zamrazil V
P268 A managed clinical network for thyroid disease
Cuthbertson DJR, Jung RT & Leese GP
P269 Somatostatin receptor expression in thyroid disease
England RJA, Bedford KJ, Karsai L & Atkin SL
P270 Adequacy of information delivered to patients during consultation for thyrotoxicosis
Kaushal K, Bhattacharyya A, Varghese B & Davis JRE
P271 Serum TSH and thyroid autoantibodies in thyroidal and extrathyroidal disease
Smyth PPA, Kavanagh D, Smith DF, Brennan CG, Fleming F, Hill ADK, Mc Dermott EWM, O'Higgins NJ, Barrett P, Thompson C & Moriarty MJ
P272 Comparison of simultaneous ultrasonography and radio-isotope scanning in hyperthyroid patients as compared with radio-isotope scanning alone
McGowan G, Skehan S, Collins C & O'Shea D
P273 Conventional withdrawal of thyroid suppression in differentiated thyroid carcinoma: How frequently are adequately raised TSH levels attained?
McLaughlin CM, Hunter SJ, Bell PM, McCance DR, Sheridan B & Atkinson AB
P274 High prevalence of ANCA in patients with Graves' disease treated with thionamides
Harper L, Chin L, Daykin J, Allahabadia A, Heward JM, Gough SC, Savage CO & Franklyn JA
P275 Lack of association of the interleukin 4 receptor gene with Graves' disease in the UK
Tait KF, Heward JM, Kelly MA, Barnett AH, Franklyn JA & Gough SCL
P276 Does an eosinophil/monocyte ratio help to differentiate between types of thyrotoxicosis?
Sturrock AM & Hurel SJ
P277 Acute metabolic effects of high dose intravenous methylprednisolone therapy in patients with thyroid-associated ophthalmopathy
Ahmed A, Dickinson AJ, Neoh C, Frewin S & Perros P
P278 Graves' disease presenting in the third trimester of pregnancy
McCulloch AJ, Wood R & Nag S
P279 Outcome of carbimazole, radioactive iodine and subtotal thyroidectomy in the treatment of Graves' disease at Alnour Hospital in Saudi Arabia
Karawagh AM & Abdelaziz MM
P280 Homocysteine in subclinical hypothyroidism, a risk factor for atherosclerosis?
Andrees M, Boran G, Clarke G & O Connor G

Novartis Awards Poster Session

This special session will take place at 12.45-13.15 on Tuesday 25 March in Hall 2.
NP1 Expression of adiponectin protein in human fat: The effect of type 2 diabetes and obesity
Fisher FFM, McTernan PG, McTernan CL, Chetty R, Harte AL, Valsamikis G, Barnett AH & Kumar S
NP2 Abnormalities of thyroid function in the POMC-null mouse
Martin NM, Small CJ, Sajedi A, Ghatei MA, Hochgeschwender U & Bloom SR