| Monday 5 March
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From 08:30
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Registration and coffee
Hall 3 foyer
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10:00 10:45
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Basic Review Lecture
Applications of proteomics in translational research
Hall 1
Chair: J Davis (Manchester)
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S74
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Applications of proteomics in translational research
W Kolch ( (Glasgow))
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10:45 12:45
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Molecular Endocrinology Workshop: Nuclear hormone receptor-chromatin interactions: new approaches and insight into dynamics
Hall 9
Chairs: J Gustafsson (Novum, Sweden) & C McCabe (Birmingham)
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| 10:45 |
S72
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Chip-chip approaches to understanding ER function
J Carroll ( (Boston, USA))
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| 11:45 |
S73
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Dynamics of nuclear receptor interactions on chromatin
G Hager ( (Bethesda, USA))
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10:45 12:45
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Symposium 1: Transdifferntiation in the endocrine system
The ability of specific endocrine organs to differentiate their cellular population in order to meet altered physiological requirements is important in the development of endocrine pathologies
Hall 11
Chairs: D Tosh (Bath) & S Ball (Newcastle upon Tyne)
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| 10:45 |
S9
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Fibroblasts and tissue remodelling: defining a role for fibroblasts in the persistence of chronic inflammation
C Buckley ( (Birmingham))
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| 11:15 |
S10
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Transdifferentiation in the osteoblast
M Nuttall ( (Malvern, USA))
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| 11:45 |
S11
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Plasticity of the adipose organ
S Cinti ( (Ancona, Italy))
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| 12:15 |
S12
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Pancreatic transdifferentiation and the treatment of liver damage
M Wright ( (Aberdeen))
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10:45 12:45
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Clinical Management Workshop 1: Management of endocrine disorders in pregnancy: the mother and the child
Supported by Clinical Endocrinology
Hall 1
Chairs: C Nelson-Piercy (London) & M Blot (Newcastle upon Tyne)
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| 10:45 |
S45
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Hyperglycaemia in pregnancy
D McCance ( (Belfast))
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| 11:15 |
S46
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CAH - pregnancy and antenatal glucocorticoid treatment
S Lajic ( (Stockholm, Sweden))
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| 11:45 |
S47
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Thyroid disease in pregnancy
S Mandel ( (Pennsylvania, USA))
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| 12:15 |
S48
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Maternal vitamin D status in pregnancy and risk to the child
Z Mughal ( (Manchester))
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12:45 14:15
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Lunch and posters
Hall 3
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12:50 14:05
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Open access and your research
Opening up the litrature or closing down journals?
Hall 9
Chair: S Thorn (Society for Endocrinology)
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| 12:55 |
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Open Access: what is it, and how might it affect your Society?
S Byford (Society for Endocrinology)
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| 13:14 |
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Do researchers think a move to Open Access would serve their interest better or worse?
I Rowlands (CIBER, University College London)
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| 13:40 |
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Is the 'author pays' model financially viable and does it achieve wider dissemination?
M Richardson (Managing Director, Oxford University Press)
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| 14:05 |
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Discussion
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14.15 16.15
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Symposium 2: Thyroid and autoimmunity
An update on thyroid autoimmunity: T cells, animal models, TSH receptor and clinical aspects of TSH receptor antibodies
Hall 1
Chairs: S Pearce (Newcastle upon Tyne) & R Aijan (Leeds)
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| 14:15 |
S13
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Pathogenic and regulatory T cells in a humanised model of hypothyroidism
S Quaratino (Southampton)
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| 14:45 |
S14
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Novel animal models of Grave's hyperthyroidism
S McLachlan (Los Angeles, USA)
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| 15:15 |
S15
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The TSH receptor: from natural variants to structure and function
G Vassart (Brussels, Belgium)
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| 15:45 |
S16
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TSH receptor antibodies - should we measure them and if so how?
A Weetman (Sheffield)
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14.15 16.15
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Oral Communications 1: Steroid synthesis and action
Supported by the Clinical Endocrinology Trust
Hall 11
Chairs: J Connell (Glasgow) & K Forbes (Manchester)
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| 14:15 |
OC1
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Monogenic Polycystic ovary syndrome (PCOS) due to novel mutations in the H6PD gene - Apparent Cortisone Reductase Deficiency (ACRD).
A Slabbert;
G Lavery;
J Connell;
E Walker;
P Stewart;
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| 14:30 |
OC2
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Mouse Melanocortin-2 receptor accessory protein: expression pattern and protein characterisation
I Almiro do Vale;
M Egertová;
L Guasti;
M Elphick;
A Clark;
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| 14:45 |
OC3
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Transcriptional regulation of 11beta-hydroxysteroid dehydrogenase type 1 under the synergistic control of glucocorticoids and cytokines
K Kaur;
G Lavery;
E Walker;
P Stewart;
M Hewison;
M Cooper;
E Rabbitt;
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| 15:00 |
OC4
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Modulation of membrane initiated glucocorticoid signalling by caveolin-1
L Matthews;
A Berry;
J Ohanian;
V Ohanian;
D Ray;
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| 15:15 |
OC5
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Hexose-6-phosphate dehydrogenase: a novel regulator of glucocorticoid hormone action
Society for Endocrinology/Clinical Endocrinology Trust Young Endocrinologist Basic Science Prize Lecture
G Lavery;
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| 15:45 |
OC6
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A novel tethering mechanism explains cell type specific glucocorticoid repression of macrophage migration inhibitory factor (MIF)
L Elsby;
Z Alourfi;
R Donn;
D Ray;
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| 16:00 |
OC7
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Differential effects of P450 oxidoreductase mutants on CYP17 activity provides evidence for an alternative pathway in human androgen biosynthesis
V Dhir;
H Ivison;
N Krone;
P Stewart;
C Shackleton;
W Arlt;
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14.15 16.15
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Oral communications 2: Clinical and translational endocrinology
Hall 9
Chairs: S Gough (Birmingham) & A Munir (Sheffield)
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| 14:15 |
OC8
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Effect of once-yearly infusion of zoledronic acid 5mg in postmenopausal women with osteoporosis
R Eastell;
D Black;
J Cauley;
F Cosman;
S Cummings;
P Delmas;
E Eriksen;
W Fraser;
T Hue;
P Lakatos;
P Leung;
Z Man;
A McLellan;
P Mesenbrink;
D Reid;
I Reid;
S Boonen;
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| 14:30 |
OC9
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A novel homozygous inactivating mutation, Pro339Thr, of the calcium-sensing receptor is associated with isolated primary hyperparathyroidism
F Hannan;
M Nesbit;
P Christie;
W Lissens;
M Bex;
R Bouillon;
R Thakker;
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| 14:45 |
OC10
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Expression of the orphan nuclear receptors oestrogen receptor related (ERR) alpha and beta in the human endometrium: implications for oestrogen receptor signalling.
V Bombail;
S MacPherson;
K Kerr;
F McGarry;
H Critchley;
P Saunders;
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| 15:00 |
OC11
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Reduced 5α-reductase activity in peripheral blood mononuclear cells in polycystic ovarian syndrome - a compensatory mechanism for androgen excess ?
F Hammer;
N Bozhinova;
B Hughes;
M Fassnacht;
P Stewart;
B Allolio;
W Arlt;
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| 15:15 |
OC12
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Local and systemic consequences of glucocorticoid metabolism in synovium
R Hardy;
M Cooper;
P Stewart;
C Buckley;
K Raza;
E Rabbitt;
M Cooper;
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| 15:30 |
OC13
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Relative protection of cortical bone in women with complete androgen insensitivity syndrome compared to women with gonadal dysgensis
T Han;
D Goswami;
S Trikudanathan;
S Creighton;
G Conway;
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| 15:45 |
OC14
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A two-centre experience of long-term pegvisomant therapy in 58 patients
C Higham;
T Chung;
W Drake;
P Trainer;
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| 16:00 |
OC15
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Biological variability of Insulin resistance in polycystic ovarian syndrome after treatment with metformin, orlistat and pioglitazone
L Cho;
S Gonzalez;
S Holding;
E Kilpatrick;
S Atkin;
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16.15 16.35
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Tea
Hall 3
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16.35 17.05
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Society for Endocrinology Annual General Meeting
Hall 1
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17.10 18.00
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Society for Endocrinology Dale Medal Lecture
Dale Medallist Professor Steven Lamberts will discuss the pathophysiology of somatostatin receptors in man, demonstrating how every part of the course of events from ligand-receptor binding and internalisation to the activation of intracellular pathways has been translated in clinically meaningful applications
Hall 3
Chair: J Wass (Oxford)
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S1
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The ever-expanding role of somatostatin receptors in endocrine disease
S Lamberts (Rotterdam, The Netherlands)
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18.00 19.30
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Welcome Reception
Hall 3
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