| Monday 7 April
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09.00 onwards
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Registration
Main Foyer
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10.30 12.30
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Bone and Mineral Special Interest Group Satellite: Osteoporosis
In association with the National Osteoporosis Society
Generously supported by Novartis & Roche
Queen's Suite 2
Chairs: J Wass (Oxford) & R Eastell (Sheffield)
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| 10.30 |
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Reception
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| 11.00 |
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Chairman's introduction: osteoporosis - the silent epidemic?
J Wass (Oxford) & R Eastell (Sheffield)
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| 11.10 |
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NICE ways to manage osteoporosis
P Selby (Manchester)
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| 11.30 |
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'But doctor I can't take generic alendronic acid!'
R Eastell (Sheffield)
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| 11.50 |
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'But doctor no guidelines apply to my situation'
S Orme (Leeds)
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| 12.10 |
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So you want to set up an osteoporosis service?
A McLellan (Glasgow)
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10.30 12.30
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Andrology Special Interest Group Satellite: Controversies in the diagnosis and management of hypogonadism
Generously supported by Bayer Schering Pharma & ProStrakan
Queen's Suite 1
Chair: H Jones (Sheffield)
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| 10.30 |
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Hypogonadism and diabetes
H Jones (Sheffield)
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| 10.50 |
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Aging, frailty and testosterone
F Wu (Manchester)
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| 11.10 |
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Difficulties in the diagnosis of hypogonadism
S Arver (Stockholm, Sweden)
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| 11.30 |
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Testosterone and prostate safety
M Feneley (London)
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| 11.50 |
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Discussion
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12.30 13.00
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Lunch
Hall Q
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13:00 15:00
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Symposium 1: New twists in appetite/satiety signalling pathways
King's Suite
Chairs: S O'Rahilly (Cambridge) & K Smith (London)
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| 13.00 |
S9
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Plasma triglycerides and appetite control
W Banks (St Louis, USA)
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| 13.30 |
S10
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Imaging the brain appetite network
S Luckman (Manchester)
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| 14.00 |
S11
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Role of central serotonin 2C receptors in appetite control
L Heisler (Cambridge)
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| 14.30 |
S12
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Central role of AMP-Kinase in appetite control
M Korbonits (London)
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13:00 15:00
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Clinical Management Workshop 1: Fibrous dysplasia and McCune-Albright syndrome
Supported by Clinical Endocrinology
Main Auditorium
Chairs: R Thakker (Oxford) & M Cooper (Birmingham)
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| 13.00 |
S44
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The endocrine consequences of McCune-Albright syndrome
P Trainer (Manchester)
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| 13.40 |
S45
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Molecular genetics and cell biology of McCune-Albright syndrome and fibrous dysplasia
L Weinstein (Bethesda, USA)
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| 14.20 |
S46
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Medical treatment of fibrous dysplasia of bone
R Chapurlat (Lyon, France)
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13:00 15:00
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Molecular Endocrinology Workshop
Queen's Suite 1
Chairs: M Gurnell (Cambridge) & K Boelaert (Birmingham)
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| 13.00 |
S70
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Cell metabolomics: differential metabolism of glucose and fructose in pancreatic cancer
T Heaney (Los Angeles, USA)
|
| 14.00 |
S71
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Combining mouse genetics, transgenics and knockouts to explore the biology of MC1R aganism and antagonism
I Jackson (Edinburgh)
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15:00 15:30
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Coffee
Hall Q
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15:30 17:30
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Symposium 2: System-specific effect steroids
King's Suite
Chairs: S Lightman (Bristol) & G Lavery (Birmingham)
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| 15.30 |
S13
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Glucocorticoid signalling in the brain
S Lightman (Bristol)
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| 16.00 |
S14
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Glucocorticoids, 11beta HSDs and neuroprotection
M Holmes (Edinburgh)
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| 16.30 |
S15
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Glucocorticoids, liver, fat and metabolic syndrome
P Stewart (Birmngham)
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| 17.00 |
S16
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Glucocorticoids, folliculo-stellate cells and the pituitary
H Christian (Oxford)
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15:30 17:30
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Oral Communications 1: Young Endocrinologists Prize Session
Main Auditorium
Chairs: J Wass (Oxford) & A McNeilly (Edinburgh)
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| 15.30 |
OC1
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Clinical manifestations of familial paraganglioma and phaeochromocytomas in succinate dehydrogenase B gene mutation carriers
U Srirangalingam;
L Walker;
B Khoo;
F MacDonald;
D Gardner;
T Wilkin;
R Skelly;
E George;
D Spooner;
J Monson;
A Grossman;
S Akker;
P Pollard;
N Plowman;
N Avril;
D Berney;
J Burrin;
R Reznek;
V Kumar;
E Maher;
S Chew;
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| 15.45 |
OC2
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The ghrelin-cannabinoid axis – a novel pathway in the regulation of appetite and metabolism
F Amin;
B Kola;
M Christ-Crain;
F Lolli;
G Wittmann;
J Harvey-White;
G Kunos;
A Grossman;
C Fekete;
M Korbonits;
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| 16.00 |
OC3
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Does 11beta-HSD1 in visceral adipose tissue (VAT) deliver cortisol to the liver? Studies with portal vein sampling and tracer infusion in humans.
R Stimson;
R Andrew;
D Redhead;
P Hayes;
B Walker;
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| 16.15 |
OC4
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Hypoxia and GC signalling regulate macrophage migration inhibitory factor (MIF) gene expression through a common element
L Elsby;
R Donn;
Z Alourfi;
E Beaulieu;
D Ray;
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| 16.30 |
OC5
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Placental vascular development and nutrient transport in 11ß-HSD2-/-mice
C Wyrwoll;
J Seckl;
M Holmes;
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| 16.45 |
OC6
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MRAP2 permits the functional expression of the melanocortin-2-receptor: a new member of a new family of melanocortin receptor accessory proteins
L Chan;
L Metherell;
M Elphick;
J Chapple;
A Clark;
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| 17.00 |
OC7
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Testosterone treatment improves muscle strength, lean mass and quality of life in prefrail and frail elderly men: Results from a randomised double-blind placebo-controlled study
U Srinivas-Shankar;
S Roberts;
J Adams;
M Connolly;
J Oldham;
F Wu;
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| 17.15 |
OC8
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β-cell 11β-Hydroxysteroid dehydrogenase type 1 contributes to Type 2 Diabetes.
S Turban;
L Ramage;
J Paterson;
J Mullins;
J Seckl;
N Morton;
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15:30 17:30
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Oral Communications 2: Reproduction
Queen's Suite 1
Chairs: H Critchley (Edinburgh) & J Prague (London)
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| 15.30 |
OC9
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Dynamic responses of oestrogen receptors revealed by fluorescent recovery after photobleaching (FRAP)
C Fitzgerald;
F Collins;
P Brown;
V Bombail;
K Kerr;
S Macpherson;
M Millar;
P Saunders;
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| 15.45 |
OC10
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Expression of somatostatin receptors 1-5 in normal human endometrium through the menstrual cycle
E Dickerson;
K Bedford;
I Richmond;
S Maguiness;
J Robinson;
S Xu;
S Atkin;
|
| 16.00 |
OC11
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Identification of a novel compound heterozygous mutation in the gonadotrophin releasing hormone receptor in two siblings with isolated hypogonadotrophic hypogonadism
A Chesover;
S Kim;
J Ahlquist;
P Bouloux;
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| 16.15 |
OC12
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Modelling Kallmann's Syndrome in the zebrafish
S Cadman;
G Philp;
S Kim;
P Bouloux;
I Mason;
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| 16.30 |
OC13
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Effect of hypoxia and inflammatory and anti-inflammatory signals on gene expression in sheep ovarian surface epithelium (OSE) in vitro.
C Harlow;
M Rae;
D Price;
A McNeilly;
S Rhind;
S Hillier;
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| 16.45 |
OC14
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IGF-mediated cell turnover in the human placenta is positively regulated by the protein tyrosine phosphatase, SHP-2.
K Forbes;
J Aplin;
M Westwood;
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| 17.00 |
OC15
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Evaluation of the prevalence of vitamin D deficiency and its treatment in a west London pregnant population
H Salmasi;
A Banerjee;
M Donaldson;
A Wren;
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| 17.15 |
OC16
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Enhanced hypothalamic-pituitary-adrenal axis activation, 5α-reductase activity and insulin resistance distinguishes polycystic ovary syndrome from simple obesity
D Vassiliadi;
J Tomlinson;
B Hughes;
C Gay;
S Sira;
P Nightingale;
C Shackleton;
P Stewart;
W Arlt;
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17:30 17:45
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Tea
Hall Q
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17:45 18:45
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Young Endocrinologist Prize Lectures
Main Auditorium
Chairs: P Stewart (Birmingham) & A McNeilly (Edinburgh)
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| 17.45 |
S64
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Peptide YY: Food for thought
R Batterham (London)
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| 18.15 |
S65
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11b-HSD1 and metabolic disease: a mouses’ Tail
N Morton (Edinburgh)
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18:45 onwards
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Welcome Reception
Holiday Inn
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19:45 onwards
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Young endocrinologists quiz night
Generously supported by Fisher Scientific & Novo Nordisk Ltd
Hall D
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| Tuesday 8 April
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07:15 08:00
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Clinical Expert 1: Management of prolactinoma
Supported by Clinical Endocrinology
Queen's Suite 1
Chair: R Murray (Leeds)
J Bevan (Aberdeen)
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07:15 08:00
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Clinical Expert 2: Clinical management of MEN 1 or 2
Supported by Clinical Endocrinology
Queen's Suite 2
Chair: J Davis (Manchester)
R Thakker (Oxford)
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08:15 10:15
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Symposium 3: Hypoxia: its effects on physiology and pathophysiology
Queen's Suite 2
Chairs: M Westwood (Manchester) & K Forbes (Manchester)
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| 08.15 |
S17
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Hypoxia signalling and VHL
P Maxwell (London)
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| 08.45 |
S18
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Prenatal hypoxia and early origins of heart disease
D Giussani (Cambridge)
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| 09.15 |
S19
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Hypoxia, angiogenesis and proliferative diabetic retinopathy
P Bishop (Manchester)
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| 09.45 |
S20
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Understanding VEGF Action: the role of a novel factor, Dll4
S Wiegand (Regeneron Pharmaceuticals)
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08:15 10:15
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Oral Communications 3: Bone, Diabetes and Tumours
Queen's Suite 1
Chairs: R Rosenfeld (Palo Alto, USA) & A Swali (Birmingham)
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| 08.15 |
OC17
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Cinacalcet is an effective and well tolerated treatment for MEN1 associated primary hyperparathyroidism
AMEND YOUNG INVESTIGATOR AWARD WINNER
V Moyes;
K Alexandraki;
J Monson;
S Akker;
S Chew;
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| 08.30 |
OC18
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Human omental adipose tissue as a key site for the inflammatory 15-lipoxygenase pathway: Implications for metabolic disease.
M Hill;
P McTernan;
N da Silva;
K McGee;
C Kusminski;
A Baker;
S Kumar;
A Harte;
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| 08.45 |
OC19
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Expression of the parathyroid-specific transcription factor glial cell-Missing B (GCMB) is regulated by GATA3
I Grigorieva;
M Nesbit;
A Ali;
M Stechman;
R Thakker;
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| 09.00 |
OC20
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Serum 18 hydroxycortisol identifies aldosteronoma in the differential diagnosis of primary aldosteronism
S Narasimhan;
A McGregor;
J Miell;
S Chambers;
H Abraha (Daines);
S Aylwin;
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| 09.15 |
OC21
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Delineating the mechanisms of visfatin regulation in human AT and the implications of TZD treatment in type 2 diabetes
K McGee;
A Harte;
N da Silva;
S Creely;
A Baker;
C Kusminski;
M Khanolkar;
M Evans;
M Chittari;
V Patel;
S Boardman;
S Kumar;
P McTernan;
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| 09.30 |
OC22
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Cataracts are a phenotypic feature of autosomal dominant hypocalcaemia with hypercalciuria (ADHH): lessons from the Nuf mouse model with an activating calcium sensing receptor (CaSR) mutation
F Hannan;
A Curley;
P Christie;
B Harding;
M Nesbit;
M Cheeseman;
A Bron;
R Thakker;
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| 09.45 |
OC23
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Obesity resulting from Gs-alpha mutations in the maternal (but not paternal) allele is a consequence of Gs-alpha imprinting in the central nervous system
M Chen;
K Dickerson;
J Wang;
J Kelleher;
O Gavrilova;
Q Zhang;
T Xie;
L Weinstein;
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| 10.00 |
OC24
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The calcilytic agent NPS2143 rectifies hypocalcaemia in a mouse model, Nuf, that is due to an activating calcium-sensing-receptor (CaSR) mutation: Relevance to Autosomal Dominant Hypocalcaemia with Hypercalciuria
NOVARTIS AWARD WINNER
F Hannan;
G Walls;
E Kallay;
M Nesbit;
T Hough;
R Cox;
J Hu;
A Spiegel;
R Thakker;
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08:15 10:15
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Clinical Management Workshop 2 - PCOS: Impact on long term health outcomes
Supported by Clinical Endocrinology
Main Auditorium
Chairs: J Ahlquist (Southend) & T Sathyapal (Hull)
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| 08.15 |
S47
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Fat metabolism, obesity, NASH in PCOS and insulin resistant states
S Atkin (Hull)
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| 08.55 |
S48
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Cardiovascular implications of PCOS
F Orio (Naples, Italy)
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| 09.35 |
S49
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Long-term implications of PCOS in children and adolescents
K Ong (Cambridge)
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10:15 10:40
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Coffee
Hall Q
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10:40 11:25
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Society for Endocrinology Dale Medal Lecture
Main Auditorium
Chair: J Wass (Oxford)
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S1
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Hormones and ovaries: a lifelong journey
A McNeilly (Edinburgh)
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11:25 11:55
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Society for Endocrinology Transatlantic Medal Lecture
Main Auditorium
Chair: J Wass (Oxford)
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S2
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Insulin-like growth factors and the evolution of human growth
R Rosenfeld (Palo Alto, USA)
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12:00 13:30
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Lunch
Hall Q
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12:15 13.00
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Attended posters
Hall Q
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13:30 15:30
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Symposium 4: Thyroid hormones in development: physiology and clinical implications
Main Auditorium
Chairs: S Cheng (Bethesda, USA) & D Bassett (London)
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| 13.30 |
S21
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Thyroid Hormone Transport and Neurological Development
T Visser (Rotterdam, The Netherlands)
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| 14.00 |
S22
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New roles of deiodinases in development
A Bianco (Boston, USA)
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| 14.30 |
S23
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The HPT axis in control of skeletal development
G Williams (London)
|
| 15.00 |
S24
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Clinical implications of fetal and neonatal thyroid development
R Hume (Dundee)
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13:30 15:30
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Oral Communications 4: Pituitary and steriods
Queen's Suite 1
Chairs: J Connell (Glasgow) & O Evuarherhe (Bristol)
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| 13.30 |
OC25
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Identification of MC2R receptor accessory protein domains required for interaction with MC2R and formation of a functional ACTH responsive receptor
T Webb;
P Chapple;
L Metherell;
S Cooray;
M Cheetham;
A Clark;
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| 13.45 |
OC26
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A role for CD38 in anterior pituitary somatotrophs? Studies in CD38 null mice
S Patel;
J Prescott;
J Morris;
H Christian;
|
| 14.00 |
OC27
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Adipose GR knockdown protects against obesity in female mice
E marshall;
T Man;
N Morton;
C Kenyon;
J Seckl;
K Chapman;
|
| 14.15 |
OC28
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Pre-receptor cortisol metabolism is a critical regulator of insulin signalling in human adipose tissue
L Gathercole;
I Bujalska;
P Stewart;
J Tomlinson;
|
| 14.30 |
OC29
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Targeting Cyp11b1 expression in mice to model sequelae of congenital adrenal hyperplasia
L Mullins;
A Peter;
N Wrobel;
E Aldujaili;
J McNeilly;
D Brownstein;
A McNeilly;
J Mullins;
C Kenyon;
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| 14.45 |
OC30
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Local cortisol generation by human macrophage subsets by 11beta-hydroxysteroid dehydrogenase type 1 enzyme and its role in ocular immune privilege
V Joganathan;
A Al-Hakami;
S Rauz;
P Stewart;
G Wallace;
I Bujalska;
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| 15.00 |
OC31
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Do polyunsaturated fatty acids stimulate steroidogenesis through expression of liver x receptor?
L Barton;
P Jones;
C Wathes;
R Abayasekara;
|
| 15.15 |
OC32
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Coupling of GR cellular distribution and function to the cell cycle
L Matthews;
D Spiller;
C Rivers;
M Norman;
M White;
D Ray;
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13:30 15:30
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Young Endocrinologist Session: Obtaining funding for Young Endocrinologists
Queen's Suite 2
Chairs: K Jonas (London) & A Munir (Sheffield)
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| 13.30 |
S66
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Funding for research fellowships
T Skerry (Sheffield)
|
| 14.00 |
S67
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Clinical Research Fellowships: an insider’s account
F Swords (London)
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| 14.30 |
S68
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Basic science research lectureships: a day in the life of ...
M Westwood (Manchester)
|
| 15.00 |
S69
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The 'been-to-America' degree revisited: is it really still worth it?
R Fowkes (London)
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15:30 16:00
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Tea
Hall Q
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16:00 18:00
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Clinical Debate: This house believes that males become menopausal
Supported by Clinical Endocrinology
Main Auditorium
Chair: F Wu (Manchester)
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D1
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For
P Bouloux (London)
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D2
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Against
A Andersson (Copenhagen, Denmark)
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16:00 18:00
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Oral Communications 5: Thyroid
Queen's Suite 1
Chairs: S Cheng (Bethesda, USA) & P Beck-Peccoz (Milan, Italy)
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| 16.00 |
OC33
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Effect of thyroid status on the skeleton in post-menopausal women: the OPUS study
NOVARTIS AWARD WINNER
E Murphy;
C Glüer;
D Reid;
D Felsenberg;
C Roux;
R Eastell;
G Williams;
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| 16.15 |
OC34
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Maternal isodisomy for a novel human FOXE1 gene mutation in syndromic congenital hypothyroidism
M Castanet;
U Mallya;
M Agostini;
C Mitchell;
M Polak;
S Demuth;
L Raymond;
M Gurnell;
K Chatterjee;
|
| 16.30 |
OC35
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Circulating endothelial progenitor cells are reduced in subclinical and overt hypothyroidism
A Shakoor;
A Aldibbiat;
L Ingoe;
S Campbell;
L Sibal;
J Isaacs;
J Shaw;
P Home;
J Weaver;
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| 16.45 |
OC36
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Increased skeletal mineralisation in mice lacking type 2 iodothyronine deiodinase
J Bassett;
A Boyde;
P Howell;
T Galliford;
M Archanco;
D St. Germain;
V Galton;
G Williams;
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| 17.00 |
OC37
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Endocytosis involves a CLC-5 and KIF3B Interaction: relevance to thyroid and renal tubular function.
A Reed;
N Loh;
J Lippiat;
C Partridge;
J Galvanovskis;
S Williams;
F Jouret;
F Wu;
P Courtoy;
M Nesbit;
O Devuyst;
P Rorsman;
F Ashcroft;
R Thakker;
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| 17.15 |
OC38
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Serious vascular events for patients on long-term thyroxine: the TEARS Study
G Leese;
R Jung;
R Flynn;
|
| 17.30 |
OC39
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HIF-1α is a common downstream target of PI3K and MAPK/ERK signalling in thyroid carcinomas
K Williams;
R Cowen;
R von Wasielewski;
M Uenalan;
J Resch;
C West;
G Brabant;
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| 17.45 |
OC40
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Direct actions of T3 in proliferating chondrocytes regulate endochondral ossification and linear growth
BRITISH THYROID ASSOCIATION AWARD WINNER
N Bernstein;
R Swinhoe;
M Kester;
M Archanco;
Y Lu;
P O'Shea;
T Visser;
J Bassett;
G Williams;
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16:00 18:00
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Symposium 5: Androgen receptors – physiology and disease
Queen's Suite 2
Chairs: I McEwan (Aberdeen) & V Bombail (Edinburgh)
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| 16.00 |
S25
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Tissue-specific androgen receptor knockout models: novel tools in the study of androgen action
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