| Tuesday 8 April
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07:15 08:00
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Clinical Expert 1: Management of prolactinoma
Supported by Clinical Endocrinology
Queen's Suite 1
Chair: R Murray (Leeds)
J Bevan (Aberdeen)
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07:15 08:00
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Clinical Expert 2: Clinical management of MEN 1 or 2
Supported by Clinical Endocrinology
Queen's Suite 2
Chair: J Davis (Manchester)
R Thakker (Oxford)
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08:15 10:15
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Symposium 3: Hypoxia: its effects on physiology and pathophysiology
Queen's Suite 2
Chairs: M Westwood (Manchester) & K Forbes (Manchester)
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| 08.15 |
S17
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Hypoxia signalling and VHL
P Maxwell (London)
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| 08.45 |
S18
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Prenatal hypoxia and early origins of heart disease
D Giussani (Cambridge)
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| 09.15 |
S19
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Hypoxia, angiogenesis and proliferative diabetic retinopathy
P Bishop (Manchester)
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| 09.45 |
S20
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Understanding VEGF Action: the role of a novel factor, Dll4
S Wiegand (Regeneron Pharmaceuticals)
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08:15 10:15
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Oral Communications 3: Bone, Diabetes and Tumours
Queen's Suite 1
Chairs: R Rosenfeld (Palo Alto, USA) & A Swali (Birmingham)
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| 08.15 |
OC17
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Cinacalcet is an effective and well tolerated treatment for MEN1 associated primary hyperparathyroidism
AMEND YOUNG INVESTIGATOR AWARD WINNER
V Moyes;
K Alexandraki;
J Monson;
S Akker;
S Chew;
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| 08.30 |
OC18
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Human omental adipose tissue as a key site for the inflammatory 15-lipoxygenase pathway: Implications for metabolic disease.
M Hill;
P McTernan;
N da Silva;
K McGee;
C Kusminski;
A Baker;
S Kumar;
A Harte;
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| 08.45 |
OC19
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Expression of the parathyroid-specific transcription factor glial cell-Missing B (GCMB) is regulated by GATA3
I Grigorieva;
M Nesbit;
A Ali;
M Stechman;
R Thakker;
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| 09.00 |
OC20
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Serum 18 hydroxycortisol identifies aldosteronoma in the differential diagnosis of primary aldosteronism
S Narasimhan;
A McGregor;
J Miell;
S Chambers;
H Abraha (Daines);
S Aylwin;
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| 09.15 |
OC21
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Delineating the mechanisms of visfatin regulation in human AT and the implications of TZD treatment in type 2 diabetes
K McGee;
A Harte;
N da Silva;
S Creely;
A Baker;
C Kusminski;
M Khanolkar;
M Evans;
M Chittari;
V Patel;
S Boardman;
S Kumar;
P McTernan;
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| 09.30 |
OC22
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Cataracts are a phenotypic feature of autosomal dominant hypocalcaemia with hypercalciuria (ADHH): lessons from the Nuf mouse model with an activating calcium sensing receptor (CaSR) mutation
F Hannan;
A Curley;
P Christie;
B Harding;
M Nesbit;
M Cheeseman;
A Bron;
R Thakker;
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| 09.45 |
OC23
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Obesity resulting from Gs-alpha mutations in the maternal (but not paternal) allele is a consequence of Gs-alpha imprinting in the central nervous system
M Chen;
K Dickerson;
J Wang;
J Kelleher;
O Gavrilova;
Q Zhang;
T Xie;
L Weinstein;
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| 10.00 |
OC24
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The calcilytic agent NPS2143 rectifies hypocalcaemia in a mouse model, Nuf, that is due to an activating calcium-sensing-receptor (CaSR) mutation: Relevance to Autosomal Dominant Hypocalcaemia with Hypercalciuria
NOVARTIS AWARD WINNER
F Hannan;
G Walls;
E Kallay;
M Nesbit;
T Hough;
R Cox;
J Hu;
A Spiegel;
R Thakker;
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08:15 10:15
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Clinical Management Workshop 2 - PCOS: Impact on long term health outcomes
Supported by Clinical Endocrinology
Main Auditorium
Chairs: J Ahlquist (Southend) & T Sathyapal (Hull)
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| 08.15 |
S47
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Fat metabolism, obesity, NASH in PCOS and insulin resistant states
S Atkin (Hull)
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| 08.55 |
S48
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Cardiovascular implications of PCOS
F Orio (Naples, Italy)
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| 09.35 |
S49
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Long-term implications of PCOS in children and adolescents
K Ong (Cambridge)
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10:15 10:40
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Coffee
Hall Q
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10:40 11:25
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Society for Endocrinology Dale Medal Lecture
Main Auditorium
Chair: J Wass (Oxford)
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S1
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Hormones and ovaries: a lifelong journey
A McNeilly (Edinburgh)
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11:25 11:55
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Society for Endocrinology Transatlantic Medal Lecture
Main Auditorium
Chair: J Wass (Oxford)
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S2
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Insulin-like growth factors and the evolution of human growth
R Rosenfeld (Palo Alto, USA)
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12:00 13:30
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Lunch
Hall Q
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12:15 13.00
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Attended posters
Hall Q
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13:30 15:30
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Symposium 4: Thyroid hormones in development: physiology and clinical implications
Main Auditorium
Chairs: S Cheng (Bethesda, USA) & D Bassett (London)
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| 13.30 |
S21
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Thyroid Hormone Transport and Neurological Development
T Visser (Rotterdam, The Netherlands)
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| 14.00 |
S22
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New roles of deiodinases in development
A Bianco (Boston, USA)
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| 14.30 |
S23
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The HPT axis in control of skeletal development
G Williams (London)
|
| 15.00 |
S24
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Clinical implications of fetal and neonatal thyroid development
R Hume (Dundee)
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13:30 15:30
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Oral Communications 4: Pituitary and steriods
Queen's Suite 1
Chairs: J Connell (Glasgow) & O Evuarherhe (Bristol)
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| 13.30 |
OC25
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Identification of MC2R receptor accessory protein domains required for interaction with MC2R and formation of a functional ACTH responsive receptor
T Webb;
P Chapple;
L Metherell;
S Cooray;
M Cheetham;
A Clark;
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| 13.45 |
OC26
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A role for CD38 in anterior pituitary somatotrophs? Studies in CD38 null mice
S Patel;
J Prescott;
J Morris;
H Christian;
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| 14.00 |
OC27
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Adipose GR knockdown protects against obesity in female mice
E marshall;
T Man;
N Morton;
C Kenyon;
J Seckl;
K Chapman;
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| 14.15 |
OC28
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Pre-receptor cortisol metabolism is a critical regulator of insulin signalling in human adipose tissue
L Gathercole;
I Bujalska;
P Stewart;
J Tomlinson;
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| 14.30 |
OC29
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Targeting Cyp11b1 expression in mice to model sequelae of congenital adrenal hyperplasia
L Mullins;
A Peter;
N Wrobel;
E Aldujaili;
J McNeilly;
D Brownstein;
A McNeilly;
J Mullins;
C Kenyon;
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| 14.45 |
OC30
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Local cortisol generation by human macrophage subsets by 11beta-hydroxysteroid dehydrogenase type 1 enzyme and its role in ocular immune privilege
V Joganathan;
A Al-Hakami;
S Rauz;
P Stewart;
G Wallace;
I Bujalska;
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| 15.00 |
OC31
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Do polyunsaturated fatty acids stimulate steroidogenesis through expression of liver x receptor?
L Barton;
P Jones;
C Wathes;
R Abayasekara;
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| 15.15 |
OC32
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Coupling of GR cellular distribution and function to the cell cycle
L Matthews;
D Spiller;
C Rivers;
M Norman;
M White;
D Ray;
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13:30 15:30
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Young Endocrinologist Session: Obtaining funding for Young Endocrinologists
Queen's Suite 2
Chairs: K Jonas (London) & A Munir (Sheffield)
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| 13.30 |
S66
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Funding for research fellowships
T Skerry (Sheffield)
|
| 14.00 |
S67
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Clinical Research Fellowships: an insider’s account
F Swords (London)
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| 14.30 |
S68
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Basic science research lectureships: a day in the life of ...
M Westwood (Manchester)
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| 15.00 |
S69
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The 'been-to-America' degree revisited: is it really still worth it?
R Fowkes (London)
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15:30 16:00
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Tea
Hall Q
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16:00 18:00
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Clinical Debate: This house believes that males become menopausal
Supported by Clinical Endocrinology
Main Auditorium
Chair: F Wu (Manchester)
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D1
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For
P Bouloux (London)
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D2
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Against
A Andersson (Copenhagen, Denmark)
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16:00 18:00
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Oral Communications 5: Thyroid
Queen's Suite 1
Chairs: S Cheng (Bethesda, USA) & P Beck-Peccoz (Milan, Italy)
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| 16.00 |
OC33
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Effect of thyroid status on the skeleton in post-menopausal women: the OPUS study
NOVARTIS AWARD WINNER
E Murphy;
C Glüer;
D Reid;
D Felsenberg;
C Roux;
R Eastell;
G Williams;
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| 16.15 |
OC34
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Maternal isodisomy for a novel human FOXE1 gene mutation in syndromic congenital hypothyroidism
M Castanet;
U Mallya;
M Agostini;
C Mitchell;
M Polak;
S Demuth;
L Raymond;
M Gurnell;
K Chatterjee;
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| 16.30 |
OC35
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Circulating endothelial progenitor cells are reduced in subclinical and overt hypothyroidism
A Shakoor;
A Aldibbiat;
L Ingoe;
S Campbell;
L Sibal;
J Isaacs;
J Shaw;
P Home;
J Weaver;
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| 16.45 |
OC36
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Increased skeletal mineralisation in mice lacking type 2 iodothyronine deiodinase
J Bassett;
A Boyde;
P Howell;
T Galliford;
M Archanco;
D St. Germain;
V Galton;
G Williams;
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| 17.00 |
OC37
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Endocytosis involves a CLC-5 and KIF3B Interaction: relevance to thyroid and renal tubular function.
A Reed;
N Loh;
J Lippiat;
C Partridge;
J Galvanovskis;
S Williams;
F Jouret;
F Wu;
P Courtoy;
M Nesbit;
O Devuyst;
P Rorsman;
F Ashcroft;
R Thakker;
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| 17.15 |
OC38
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Serious vascular events for patients on long-term thyroxine: the TEARS Study
G Leese;
R Jung;
R Flynn;
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| 17.30 |
OC39
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HIF-1α is a common downstream target of PI3K and MAPK/ERK signalling in thyroid carcinomas
K Williams;
R Cowen;
R von Wasielewski;
M Uenalan;
J Resch;
C West;
G Brabant;
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| 17.45 |
OC40
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Direct actions of T3 in proliferating chondrocytes regulate endochondral ossification and linear growth
BRITISH THYROID ASSOCIATION AWARD WINNER
N Bernstein;
R Swinhoe;
M Kester;
M Archanco;
Y Lu;
P O'Shea;
T Visser;
J Bassett;
G Williams;
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16:00 18:00
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Symposium 5: Androgen receptors – physiology and disease
Queen's Suite 2
Chairs: I McEwan (Aberdeen) & V Bombail (Edinburgh)
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| 16.00 |
S25
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Tissue-specific androgen receptor knockout models: novel tools in the study of androgen action
G Verhoeven (Leuven, Belgium)
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| 16.40 |
S26
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Loss of androgen receptor bindingto selective androgen response elements causes a reproductive phenotype in transgenic SPARKI mice
F Claessens (Leuven, Belgium)
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| 17.20 |
S27
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Androgen receptors in development: biochemical and clinical correlates
I Hughes (Cambridge)
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16:00 17:00
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Clinical Expert 1 (repeat): Management of prolactinoma
Supported by Clinical Endocrinology
King's Suite
Chair: R Murray (Leeds)
J Bevan (Aberdeen)
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17:00 18:00
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Clinical Expert 2 (repeat): Clinical management of MEN 1 or 2
Supported by Clinical Endocrinology
King's Suite
Chair: J Davis (Manchester)
R Thakker (Oxford)
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19:30 onwards
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Society for Endocrinology banquet
Old Swan Hotel
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