Young Endocrinologist  Prize Lectures – Basic

PTTG and PBF as targets for augmenting radioiodine uptake in thyroid cancer

Dr Vicki Smith,

Birmingham

Young Endocrinologist  Prize Lecture – Clinical

RNA Interference as therapy for Cushing’s Disease.

Dr Alia Munir

Sheffield

Young Endocrinologist  Oral Communications
Best basic presentation

0283

OC3.6

Men1 gene replacement therapy using a modified adenoviral vector demonstrates reduced proliferation rates in pituitary tumours from mice deleted for a Multiple Endocrine Neoplasia Type 1 allelle.

Mahsa Javid, Gerard Walls, Manuel Lemos, Jeshmi Jeyabalan, Miriam Bazan-Peregrino, Damian Tyler, Daniel Stuckey, Len Seymour, Rajesh Thakker

Oxford

Young Endocrinologist  Oral Communications
Best clinical presentation

375

OC3.8

Identification and functional impact of novel mutations in the gene encoding 11beta-hydroxysteroid dehydrogenase type 1 in patients with hyperandrogenism

Alexander Lawson, Elizabeth Walker ,
Gareth Lavery , Iwona Bujalska , Beverly Hughes, Wiebke Arlt , Jonathan Ride
Paul Stewart

Birmingham

Best overall Basic Poster

P16

A novel GATA3 mutation, Tyr345Cys, in Hypoparathyroidism, Deafness and Renal dysplasia (HDR) syndrome results in abolished DNA binding

Irina Grigorieva (1) presenting, Katie Gaynor (1), Treena Cranston (1), Catherine McWilliam (2), Faisal Ahmed (2), M. Andrew Nesbit (1), Rajesh Thakker (1)

Oxford

Best overall clinical poster

P358

Hepatic vein cannulation and stable isotope tracer infusion reveals that liver cortisol regeneration by 11β-HSD1 is sustained in obese men with type 2 diabetes mellitus, providing a target for enzyme inhibition

Roland Stimson (1) presenting, Ruth Andrew (1), Norma McAvoy (2), Dhiraj Tripathi (2), Peter Hayes (2), Brian Walker (1)

Edinburgh

Best clinical poster 1

P101

Utilising Combined Treatment Modalities in Non-Islet Cell Tumour Hypoglycaemia [NICTH]

Rochan Agha-Jaffar (1) presenting, Rebecca Scott (1), Si Chong Lok (1), Mark Cohen (1)

London

Best clinical poster 2

P231

Phenotypic presentation of P450 oxidoreductase deficiency during puberty

Jan Idkowiak (1) presenting, Stephen O'Riordan (2), Nicole Reisch (1), Vivek Dhir (1), Ewa Malunowicz (3), Michiel Kerstens (4), Dominique Maiter (5), Felicity Collines (6), Martin Silink (7), Mehul Dattani (2), Cedric Shackleton (1), Nils Krone (1), Wiebke Arlt (1)

Birmingham

Best clinical poster 3

P116

Unemployment and Return to Work after the Diagnosis of a Chronic Endocrine Condition

Barbara Alberts (1) presenting, Emily Parker (1), John Wass (1)

Oxford

Best clinical poster4

P120

The Role of Adrenal Vein Sampling (AVS) in the Diagnosis and Management of Primary Hyperaldosteronism – an Audit of Ten Year’s Experience at a Tertiary Referral Centre.

Tom Hopkins (1) presenting, Victoria Salem (1), Heba El-Gayar (1), Tricia Tan (1), Fausto Palazzo (1), Kareem Meeran (1)

London

Best Basic Poster 1

P177

Mice harbouring the Familial Juvenile Hyperuricaemic Nephropathy (FJHN) disease-causing Uromodulin (Tamm-Horsfall Glycoprotein) mutation Cys125Arg, have a urine concentrating defect, progressive renal failure, and altered uric acid handling.

Sian Piret (1) presenting, Anita Reed (1), M. Andrew Nesbit (1), Tertius Hough (2), Liz Bentley (2), Roger Cox (2), Rajesh Thakker (1)

Oxford

Best Basic Poster 2

P239

ALARIN STIMULATES FOOD INTAKE AND THE HYPOTHALAMO-PITUITARY-GONADAL AXIS IN MALE RATS

Charlotte Boughton (1) presenting, Michael Patterson (1), Gavin Bewick (1), John Tadross (1), James Gardiner (1), Faizan Chaudery (1), George Hunter (1), Mohammad Ghatei (1), Stephen Bloom (1), Kevin Murphy (1)

London

Best Basic Poster 3

P124

PTTG promotes mitogenic mechanisms in thyroid cells through autocrine pathways of interaction with TGF-alpha , EGF and IGF-1

Greg Lewy (1) presenting, Gavin Ryan (1), Martin Read (1), Vicki Smith (1), Jim Fong (1), Adrian Warfield (1), Margaret Eggo (1), Robert Seed (1), Neil Sharma (1), Kwan Perkin (1), Jayne Franklyn (1), Christopher McCabe (1), Kristien Boelaert (1)

Birmingham

Best Basic Poster 4

P169

MOPDII and Alström Syndrome: two centrosomopathies featuring severe insulin resistance and impaired adipogenesis

Isabel Huang-Doran (1) presenting, Keith Porter (1), Stephen O'Rahilly (1), Andrew Jackson (2), Robert Semple (1)

Cambridge

461

P340

Winner
Steroid therapy: an unusual alternative to oral replacement via 24 hour subcutaneous infusion device.

Susan Stewart, Parth Narendon, Barbara Hudson, Peter Hindmarsh, Nils Krone, Wiebke Arlt

W Midlands Clinical Genetics Unit

Annette Louise Seal Award, Addisons Self Help Group

26

P331

Runner Up Steroid therapy: an unusual alternative to oral replacement via 24 hour subcutaneous infusion device.

Jean Munday, Lina Chong, Partha Kar,

Portsmouth Hospitals NHS Trust

AMEND Young Endocrinologist Award

0455

OC3.3

Development of urinary steroid profiling as a high-throughput screening tool for the detection of malignancy in patients with adrenal tumours

Angela Taylor, Wiebke Arlt, Michael Biehl, Beverly Hughes, Han Stiekema, Petra Schneider, David Smith, Peter Nightingale, Cedric Shackleton, Paul Stewart, Wiebke Arlt

Birmingham

AMEND Young Endocrinologist Award – Joint winner

43

OC2.4

Geographical cluster of familial isolated pituitary adenoma kindreds with an identical AIP mutation

Zehra Ozfirat, Josh Cain, Harvinder Chahal, Karen Stals, Sian Ellard, Trevor Howlett, Miles Levy, Brew Atkinson, Patrick Morrison, Scott Akker, Ashley Grossman, Marta Korbonits

London

British Thyroid Association Award

0238

OC3.5

A Multisystem Selenoprotein Disorder with a Thyroid Signature

Nadia Schoenmakers1, Erik Schoenmakers1, Maura Agostini1, Catherine Mitchell1, Laura Papp2, Odelia Rajanayagam1, Raja Padidela3, Rainer Doffinger4, Jian’an Luan5, Jun Lu6, Irene Campi1, Hannah Burton1, Francesco Muntoni7, Dominic O’Donovan8, Andrew Dean8, Anne Warren8, Pascale Guicheney9, Rebecca Fitzgerald10, Alasdair Coles11, Hill Gaston12, Arne Holmgren6, Marcus S. Cooke13, David Halsall14, Nicholas Wareham5, Paolo Beck-Peccoz15, Arthur Ogunko16, Mehul Dattani3, Mark Gurnell1, Krishna Chatterjee1

Cambridge

Clinical Endocrinology Trust  (CET) Nurse award

0139

P406

Diagnostic and financial benefits of checking TSH receptor antibodies in patients with thyrotoxicosis

Violet Fazal-Sanderson, Niki Karavitaki, Theingi Aung, John AH Wass,

Oxford

CET Basic

0428

OC1.5

The immune-adrenal interface: effects of endotoxin on annexin 1 and formyl peptide receptor expression, cellular morphology and steroidogenesis in the mouse adrenal cortex.

Nicholas Buss, Felicity Gavins, Stephanie Gresham, Patricia Cover, Andrea Terron,  Julia Buckingham, 

GSK/Imperial

CET Case Presentation

0447

OC2.7

The Spectrum of Disease in Diazoxide Responsive Hyperinsulinaemic Hypoglycaemia.

Dr Mars Skae, Rakesh Amin, Leena Patel, Helena Gleeson, Sarah Ehtisham, Mohammed Didi, Jo Blair, Urmi Das,  Lindsey Rigby, Oliver Blankenstein, Sian Ellard, Anna Kelsey, Peter Clayton, Indraneel Banerjee,  Catherine Hall

Manchester Childrens Hospital

CET Clinical Practice

0375

OC3.8

Identification and functional impact of novel mutations in the gene encoding 11beta-hydroxysteroid dehydrogenase type 1 in patients with hyperandrogenism

Dr Elizabeth Walker, Alexander Lawson, Elizabeth Walker, Gareth Lavery, Iwona Bujalska, Beverly Hughes, Wiebke Arlt, Jonathan Ride, Paul Stewart,

Birmingham