Society for Endocrinology - a world-leading authority on hormones


International Medal Lecture: Dr. David J. Mangelsdorf is the Alfred G. Gilman Professor and Chair of the Department of Pharmacology at the University of Texas Southwestern Medical Center in Dallas, an Investigator of the Howard Hughes Medical Institute and a member of the National Academy of Sciences.


Dr. David Mangelsdorf

| University of Texas Southwestern Medical Center

Dr. David J. Mangelsdorf is the Alfred G. Gilman Professor and Chair of the Department of Pharmacology at the University of Texas Southwestern Medical Center in Dallas, an Investigator of the Howard Hughes Medical Institute and a member of the National Academy of Sciences. Dr. Mangelsdorf received his B.S. in Biology and Chemistry from Northern Arizona University in Flagstaff and his Ph.D. in Biochemistry from the University of Arizona in Tucson. He did his postdoctoral training at The Salk Institute for Biological Studies at the Salk Institute. During his career, he discovered the hormonal ligands and biological pathways for several nuclear receptors, including the RXRs, LXRs, FXR, and DAF-12. Dr. Mangelsdorf currently runs a joint laboratory with Dr. Steven Kliewer, and more recently their research team discovered two signaling pathways mediated by the endocrine factors FGF19 and FGF21, which govern metabolism and behavior in response to nutrient stress. Their research has uncovered several therapeutic targets that are being developed to treat diverse diseases such as obesity, diabetes, fatty liver disease, cholestasis, pancreatitis, and even nematode parasitism.

 

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