11 Apr 2012
Their study demonstrates that maternal obesity at conception affects the protein profile of human placenta, which may have implications for foetal growth and development. Proteomic analysis of placenta revealed differential expression of several proteins in patients with pre-existing obesity. These proteins are implicated in a variety of cellular functions such as regulation of growth, cytoskeletal structure, oxidative stress, inflammation, coagulation and apoptosis. These disturbances may have significant implications for foetal growth and development. Oliva et al. (2012) Journal of Molecular Endocrinology 48 139-149.
Read the full article at DOI:10.1530/JME-11-0123.