11 Apr 2012
Otabe et al. therefore conducted the present study to elucidate the mechanism involved in the longevity effects of adiponectin using KK/Ta mice, a murine model of metabolic syndrome. The lifespan of KK/Ta mice was shorter than that of control mice. Adiponectin prevented premature death in these mice without affecting body weight or daily food consumption. The longevity effect of adiponectin was not attributable to the prevention of neoplasms or cardiovascular disease, or to the upregulated Sirt1 expression. The observations in this study suggest that adiponectin may slow the accelerated aging process associated with the metabolic syndrome by inhibiting AKT signaling, thereby attenuating chronic low-grade inflammation. Otabe et al. (2012) Journal of Endocrinology 213 67-76.
Read the full article at: DOI: 10.1530/JOE-11-0329