Update on Emergency Hydrocortisone Injections

Message from the Society for Endocrinology Nurse and Clinical Committee

The Nurse and Clinical Committee would like to update members on recent changes to the supply of emergency hydrocortisone injections in the UK.

Discontinuation of Hydrocortisone Sodium Phosphate Injection

ADVANZ Pharma has confirmed that hydrocortisone sodium phosphate 100 mg/mL solution for injection has been permanently discontinued due to manufacturing difficulties.

Emergency treatment remains available

Importantly, treatment for adrenal crisis remains available.

Emergency hydrocortisone can still be administered using hydrocortisone sodium succinate powder for reconstitution, which continues to be supplied in the UK. This formulation works in exactly the same way in the body but must be mixed with sterile water immediately before injection.

We recognise that this preparation involves additional steps and may feel more challenging, particularly during a time-critical emergency. 

Message to our nurse and clinical members

As clinicians, we recognise the challenges this change presents for both practice and patient confidence. We encourage members to:

• Prioritise patient education and reassurance
• Provide hands-on training in injection preparation and administration
• Review emergency kits with patients
• Involve family members or carers in training where appropriate
• Direct patients to relevant patient support groups:
  • The Pituitary Foundation: Important update on liquid hydrocortisone supply
  • Addison’s Disease Self Help Group: Liquid Hydrocortisone Discontinued