Monday 2 November 2015
09:00   Registration
Strathblane Hall
10:30 12:00  Skills 1: Working with the media
Sidlaw
Chair: Saffron Whitehead (London)
10:30SK1.1Why should we engage with the media?
Richard Quinton (Newcastle upon Tyne)
   
10:52SK1.2Working with press officers to promote your research
Society for Endocrinology Press Office
   
11:14SK1.3What journalists need from scientists
Kenneth MacDonald (BBC)
   
11:37SK1.4When hormones hit the headlines
Alice Kay (Science Media Centre)
   
10:30 12:00  Symposium 1: Endocrinology meets the environment
Nutrition and habits meet hormones
Supported by Endocrine Connections
Fintry
Chairs: Matthew Simmonds (Oxford) & Martin Read (Birmingham)
10:30S1.1Later life consequences of maternal vitamin D deficiency - MAVIDOS Study
Nick Harvey (Southampton)
   
11:00S1.2Iodine deficiency
Mark Vanderpump (London)
   
11:30S1.3Environmental influences on autoimmunity
Wilmar Wiersinga (Amsterdam, The Netherlands)
   
10:30 12:00  Symposium 2: Zoning in on adrenal tumours
Illuminating the recent advances in genetic causes of adrenal tumours and hypertension
Supported by Endocrine-Related Cancer
Main Hall, Pentland
Chairs: Marie Freel (Glasgow) & Scott MacKenzie (Glasgow)
10:30S2.1Somatic mutations and adrenal remodelling in hyperaldosteronism
Morris Brown (Cambridge)
   
11:00S2.2Advances in genetic causes of adrenal Cushing’s
Felix Beuschlein (Munich, Germany)
   
11:30S2.3The new genetics of phaeochromocytoma
Anne-Paule Gimenez-Roqueplo (Paris, France)
   
10:30 12:00  Symposium 3: Fanning the flames of mitochondrial function
Mitochondrial decline and dysfunction is a common theme in many disease states. Identifying strategies that improve mitochondrial function
Moorfoot & Kilsyth
Chairs: Paul Chapple (London) & Craig Doig (Birmingham)
10:30S3.1Novel regulation of fat metabolism in cancer
Natalie German (Boston, MA, USA)
   
11:00S3.2Mitochondrial protein homeostasis in the control of metabolism and aging
Riekelt Houtkooper (Amsterdam, The Netherlands)
   
11:30S3.3Mitochondrial disease: problems and solutions
Doug Turnball (Newcastle upon Tyne)
   
12:15 13:00  Meet the Expert 1: Cutting edge imaging of whole endocrine organs
Supported by Clinical Endocrinology
Sidlaw
Chair: Julian Davis (Manchester)
12:15MTE1Cutting edge imaging of whole endocrine organs
Supported by Clinical Endocrinology
Helen Christian (Oxford)
   
12:15 13:00  Meet the Expert 2: T4 vs T4/T3 – evidence vs expectations?
Supported by Clinical Endocrinology
Main Hall, Pentland
Chair: Graham Leese (Dundee)
12:15MTE2T4 vs T4/T3 – evidence vs expectations?
Graham Williams (London)
   
12:15 13:00  Futures 1: Branching out with endocrinology
Making the most out of your degree(s) – matching your skills to academic careers
Fintry
Chairs: Ruth Andrew (Edinburgh) & Samantha Mirczuk (London)
12:15FUT1.1Insights into career patterns for graduates of a biological sciences degree
Susan Bird (Edinburgh)
   
12:25FUT1.2From postdoc to P.I. – transition to independence
Andrew Childs (London)
   
12:35FUT1.3The secret life of a core facilities manager
Natalie Homer (London)
   
12:45FUT1.4Panel discussion
   
12:15 13:00  Futures 2: Overcoming the consultancy hurdle
Shaping the future of endocrinology and diabetes
Moorfoot & Kilsyth
Chairs: Miles Levy (Leicester) & Sheba Jarvis (London)
12:15FUT2.1Perspective of a next generation consultant
Partha Kar (Portsmouth)
   
12:25FUT2.2Perspective of an established consultant
Paul Stewart (Leeds)
   
12:35FUT2.3Research pathways in endocrinology – a UK and global perspective
Waljit Dhillo (London)
   
12:45FUT2.4Panel discussion
   
13:00 14:15  Lunch & poster viewing
Exhibition Hall, Lennox Suite
13:00 14:15  Otsuka Satellite: Which way now in hyponatraemia? Reviewing new consensus guidelines
Sidlaw
Chair: Ashley Grossman (Oxford)
Current thinking in the management of hyponatraemia and SIADH
Aled Rees (Cardiff)
   
Interactive case studies
Robert Murray (Leeds)
   
13:00 14:15  Pfizer Satellite: Treatment resistance in Acromegaly
Moorfoot & Kilsyth
Chair: John Ayuk (Birmingham)
Challenges in acromegaly - resistance to somatostatin analogues
Niki Karavitaki (Birmingham)
   
Managing treatment resistance in Fimilial Isolated Pituitary Adenomas
Marta Korbonits (London)
   
14:15 14:45  Plenary Lecture 1: Society for Endocrinology Starling Medal Lecture
Main Hall, Pentland
Chair: Steve O'Rahilly (Cambridge)
14:15PL1Hyperactive PI-3-Kinase signalling without hormone excess: between cancer and endocrinology
Robert Semple (Cambridge)
   
14:45 15:15  Plenary Lecture 2: Society for Endocrinology Medal Lecture
Main Hall, Pentland
Chair: Barbara McGowan (London)
14:45PL2Kisspeptin - a vital trigger of puberty with therapeutic potential
Waljit Dhillo (London)
   
15:30 17:00  Oral Communications 1:Early Career Prize Session
Six oral communications from selected abstracts submitted by Early Career endocrinologists
Moorfoot & Kilsyth
Chairs: Brian Walker (Edinburgh) & Gerard Conway (London)
15:30OC1.1A novel pharmacological approach to target LH and testosterone hypersecretion in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled multi-centre randomised clinical trial of the neurokinin B receptor antagonist AZD4901
Jyothis George (Oxford)
   
15:45OC1.2Mutations in IGSF10 cause self-limited delayed puberty, via disturbance of GnRH neuronal migration
Sasha Howard (London)
   
16:00OC1.3RNA-sequencing of mouse adrenals reveals the pathways perturbed by loss of nicotinamide nucleotide transhydrogenase
Eirini Meimaridou (London)
   
16:15OC1.4Adipose tissue-specific androgen generation fuels an adverse metabolic phenotype in patients with polycystic ovary syndrome
Michael O'Reilly (Birmingham)
   
16:30OC1.5Interaction of the MR and GR in the Nucleus and at DNA
John R. Pooley (Bristol)
   
16:45OC1.6Urine steroid metabolomics as a diagnostic tool in primary aldosteronism
Katharina Lang (Birmingham)
   
15:30 17:00  Clinical Management Workshop 1: How do I do it? (I)
Clinical tips from the experts
Supported by Clinical Endocrinology and Endocrinology, Diabetes & Metabolism Case Reports, Thyroid Eye Disease Charitable Trust and British Thyroid Foundation
Main Hall, Pentland
Chairs: John Bevan (Aberdeen) & Tristan Richardson (Bournemouth)
15:30CMW1.1How do I report and interpret a DXA scan?
Nicola Peel (Sheffield)
   
15:45CMW1.2How do I treat osteoporosis after bisphosphonates?
Neil Gittoes (Birmingham)
   
16:00CMW1.3How do I investigate and manage gynaecomastia?
Louise Bath (Edinburgh)
   
16:15CMW1.4How do I manage adrenal suppression?
Jeremy Tomlinson (Oxford)
   
16:30CMW1.5How do I prevent thyroid eye disease after radioiodine?
Petros Perros (Newcastle upon Tyne)
   
16:45CMW1.6How do I manage suspected non compliance for thyroxine replacement?
Jacqueline Gilbert (London)
   
15:30 17:00  Symposium 4: It's all in the timing: rhythms underlying endocrine systems
Exploring dynamic systems with different timescales and mechanisms
Supported by Journal of Endocrinology
Sidlaw
Chairs: Gordon Hager (Bethesda, MD, USA) & Lorna Smith (Bristol)
15:30S4.1Sleep: what endocrinologists should know about the body clock
Jon Johnston (Surrey)
   
16:00S4.2Rhythms of adrenal glucocorticoid secretion
Francesca Spiga (Bristol)
   
16:30S4.3Dynamics In Hypothalamic-Pituitary Function Over Multiple Time-scales
Paul Le Tissier (Edinburgh)
   
15:30 17:00  Symposium 5: Premature ovarian insufficiency
Ovarian follicle reserve: sequelae and management of premature depletion
Fintry
Chairs: Stephen Franks (London) & Kim Jonas (London)
15:30S5.1Determinants of ovarian follicle reserve: implications for the ageing ovary
Kate Hardy (London)
   
16:00S5.2Neurological and psychological effects of premature ovarian insufficiency
Eef Hogervorst (Loughborough)
   
16:30S5.3Management of oestrogen replacement and potential for fertility in young women with premature ovarian insufficiency
Supported by Turner Syndrome Support Society
Melanie Davies (London)
   
17:00 17:30  Tea & coffee
Exhibition Hall, Lennox Suite
17:30 18:30  Early Career Prize Lectures
The Society awards two prizes to Early Career Endocrinologists, one basic science and one clinical
Main Hall, Pentland
Chairs: Karen Chapman (Edinburgh) & Wiebke Arlt (Birmingham)
17:30ECP1.1Basic Science - The Physiology and Pharmacology of the Fasting-Induced Hormone, FGF21
Bryn Owen (London)
   
18:00ECP1.2Clinical: Kisspeptin- A ‘Key Regulator' of Reproductive Physiology, Integrating Limbic Circuits with the Regulation of Reproductive Hormones
Alexander Comninos (London)
   
18:30 19:00  Plenary Lecture 3: Society for Endocrinology Transatlantic Medal Lecture
Main Hall, Pentland
Chair: David Ray (Manchester)
18:30PL3An integrated view of nuclear receptor/chromatin interactions
Gordon Hager (Bethesda, MD, USA)
   
19:00 19:45  Debate: This house believes that patients with hypothyroidism should be offered combination treatment with T3 and T4 if they do not respond to Levothyroxine
Main Hall, Pentland
Chair: Mark Vanderpump (London)
19:00D1.1FOR
Colin Dayan (Cardiff)
   
19:20D1.2AGAINST
Tony Weetman (Sheffield)
   
19:45   Welcome Reception
Exhibition Hall, Lennox Suite
20:00 20:45  Futures 3: Why endocrinology and diabetes?
Drink and nibbles will be available
Fintry
Chairs: Karim Meeran (London) & Dominic Cavlan (London)
20:00FUT3.1What endocrinology did for me – from a consultant’s perspective
John Newell-Price (Sheffield)
   
20:10FUT3.2Let me tell you how it is – from a trainee’s perspective
Julia Prague (London)
   
20:20FUT3.3An Endocrinology Club in your medical school - from concept to reality
Parisut Kimkool (Cambridge) & Rakhee Vaja (Cambridge)
   
20:30FUT3.4Panel discussion
   
20:45   Early Career Quiz
Ticketed event
Moorfoot & Kilsyth
Tuesday 3 November 2015
08:00   Registration
Strathblane Hall
09:00 09:30  Plenary Lecture 4: Society for Endocrinology Dale Medal Lecture
Main Hall, Pentland
Chair: Graham Williams (London)
09:00PL4Calcium regulation: from rhinos to molecules
Raj Thakker (Oxford)
   
09:30 10:00  Plenary Lecture 5: British Thyroid Association Pitt-Rivers Lecture
Main hall - Pentland
Chair: Mark Vanderpump (London)
09:30PL5New insights into thyroid hormone action
Supported by the Clinical Endocrinology Trust
Anthony Hollenberg (Boston, MA, USA)
   
10:00 10:30  Tea & coffee
Exhibition Hall, Lennox Suite
10:30 12:00  Clinical Management Workshop 2: Management of pituitary disease: beyond the adenoma
Update on advanced neuroendocrinology
Main Hall, Pentland
Chairs: Helen Spoudeas (London) & Andrew Lansdown (Cardiff)
10:30CMW2.1Weird and wonderful pituitary imaging
Jane Evanson (London)
   
11:00CMW2.2How to improve management of craniopharyngioma
Steve Ball (Newcastle upon Tyne)
   
11:30CMW2.3Inflammatory and autoimmune pituitary disease
Paul Carroll (London)
   
10:30 12:00  Symposium 6: Clinical implications of thyroid genomics
Genome variations in thyroid regulation and disease
Supported by Journal of Molecular Endocrinology
Moorfoot & Kilsyth
Chairs: Mark Gurnell (Cambridge) & Vicki Smith (Birmingham)
10:30S6.1Thyroid genomics - relevance to thyroid hormone therapy
Colin Dayan (Cardiff)
   
11:00S6.2Genetic underpinning of thyroid function in health and disease
Robin Peeters (Rotterdam, The Netherlands)
   
11:30S6.3TCGA genomic characterisation of papillary thyroid carcinoma
Thomas Giordano (Ann Arbor, MI, USA)
   
10:30 12:00  Skills 2: Early Career Symposium: Effective communication: get involved, get engaged!
Successfully conveying science to the general public
Supported by Addison’s Disease Self-Help Group
Sidlaw
Chairs: Anna Mitchell (Newcastle upon Tyne) & Kate Lines (Oxford)
10:30SK2.1Engaging with the public: conveying the wonders of science
Matthew Simmonds (Oxford)
   
10:45SK2.2The battles of writing a lay summary
Jo Grey (Southborough)
   
11:00SK2.3Making science cool for kids
James Cannon (London)
   
11:15SK2.4Making your impact statement pack a punch
Raj Thakker (Oxford)
   
11:30SK2.5Making social media work for promoting and recruiting science
Victoria Parker (Cambridge)
   
11:45SK2.6Panel discussion
   
10:30 12:00  Nurse Session 1: Multiple Endocrine Neoplasia
Holistic approach of the MEN patient
Supported by AMEND
Fintry
Chairs: Morag Middleton (Aberdeen) & Alison Milne (Aberdeen)
10:30N1.1Overview of MEN
John Ayuk (Birmingham)
   
11:00N1.2Genetics and MEN
Louise Izatt (London)
   
11:30N1.3Psychological support of the MEN patient
Kym Winter (St Albans)
   
12:15 13:00  Meet the Expert 3: Optimising fertility in teenage cancer survivors
Supported by Clinical Endocrinology
Main Hall, Pentland
Chair: Richard Quinton (Newcastle upon Tyne)
12:15MTE3Optimising fertility in teenage cancer survivors
Richard Anderson (Edinburgh)
   
12:15 13:00  Meet the Expert 4: Investigation and management of TSHoma
Supported by Clinical Endocrinology
Sidlaw
Chair: Neil Gittoes (Birmingham)
12:15MTE4Investigation and management of TSHoma
Mark Gurnell (Cambridge)
   
12:15 13:00  Meet the Expert 5: What every endocrine researcher should know about genome editing
Fintry
Chair: Vicki Smith (Birmingham)
12:15MTE5What every endocrine researcher should know about genome editing
Randall Platt (Boston, MA,USA)
   
12:15 13:00  Meet the Expert 6: Frontiers in the management of hypoparathyroidism
Supported by Clinical Endocrinology and Hypopara UK
Moorfoot & Kilsyth
Chair: Bill Fraser (Norwich)
12:15MTE6Frontiers in the management of hypoparathyroidism
Karen Winer (Bethesda, MD, USA)
   
13:00 14:15  Lunch & poster viewing
Exhibition Hall, Lennox Suite
13:00 14:15  Ipsen Satellite: Treatment of pituitary patients: What are the clinical and patients’ needs?
Moorfoot & Kilsyth
Chair: Ashley Grossman (Oxford)
The experience of acromegaly: patients’ perspectives
Antonia Brooke (Exeter)
   
Somatostatin analogue therapy for acromegaly; what matters to patients?
John Bevan (Aberdeen)
   
Thyrotropinomas (TSHomas) – do symptoms correlate with disease activity?
Mark Gurnell (Cambridge)
   
14:15 15:45  Oral Communications 2: Translational pathophysiology and therapeutics
Six oral communications from selected abstracts submitted by delegates
Sidlaw
Chairs: Anne White (Manchester) & Jyothis George (Oxford)
14:15OC2.1Dual 5-alpha reductase inhibition promotes hepatic lipid accumulation in man as a result of changes to lipid metabolism in adipose tissue and the liver
Jonathan Hazlehurst (Oxford)
   
14:30OC2.2Adrenal vein catecholamine levels and ratios: reference intervals derived from patients with primary aldosteronism
Sam O'Toole (London)
   
14:45OC2.3Further advances in diagnosis of adrenal cancer: a high-throughput urinary steroid profiling method using liquid chromatography tandem mass spectrometry (LC-MS/MS)
Angela Taylor (Birmingham)
   
15:00OC2.4Development of a long-acting growth hormone antagonist for the treatment of acromegaly
Rowena Speak (Sheffield)
   
15:15OC2.5Age at first major osteoporotic fracture in Danes aged 50 and over: influence of diabetes on mean age at fracture and one year mortality
Bo Abrahamsen (Holbæk, Denmark)
   
15:30OC2.6Treatment with the epigenetic modifying compound JQ1+ can significantly reduce the proliferation of pancreatic neuroendocrine tumours in a mouse model of multiple endocrine neoplasia type 1 (MEN1)
Kate Lines (Oxford)
   
14:15 15:45  Symposium 7: The rise and rise of the FGFs in endocrinology
The increasing understanding of FGFs in pathogenesis and treatment of diverse endocrine disease
Moorfoot & Kilsyth
Chairs: Steve O'Rahilly (Cambridge) & Andrew Lansdown (Cardiff)
14:15S7.1FGFs and hypogonadism
Nelly Pitteloud (Lausanne, Switzerland)
   
14:45S7.2FGF21: Starvation hormone to clinical drug?
Alexei Kharitonenkov (Bloomington, IN, USA)
   
15:15S7.3Targeting FGF23 in bone disease
Munro Peacock (Indianapolis, IN, USA)
   
14:15 15:45  Symposium 8: Fine-tuning of metabolic state for optimal pregnancy outcome
Thyroid and metabolic control during pregnancy
Main Hall, Pentland
Chairs: Karen Adamson (Edinburgh) & Shareen Forbes (Edinburgh)
14:15S8.1Revolutionising Type 1 diabetes metabolic control in pregnancy
Helen Murphy (Cambridge)
   
14:45S8.2Pregnancy and obesity
Rebecca Reynolds (Edinburgh)
   
15:15S8.3Autoimmune thyroid disease before and during pregnancy
Bijay Vaidya (Exeter)
   
14:15 15:45  Nurse Session 2: Nurse-led clinics
Why, how and other considerations of nurse led clinics
Fintry
Chairs: Dianne Wright (Bradford) & Sadaf Ulnasah (Birmingham)
14:15N2.1Development of a nurse-led hyperparathyroidism clinic
Louise Breen (London)
   
14:45N2.2Running a general endocrine nurse-led clinic
Chona Feliciano (Birmingham)
   
15:15N2.3Medicolegal aspects of endocrine nursing
Helen Turner (Oxford)
   
15:45 16:15  Tea & coffee
Exhibition Hall, Lennox Suite
16:15 17:45  Oral Communications 3: Steroids and adrenal
Six oral communications from selected abstracts submitted by delegates
Sidlaw
Chairs: John Connell (Dundee) & Mick O'Reilly (Birmingham)
16:15OC3.1Molecular diagnosis of patients with adrenal insufficiency using a targeted custom Haloplex next-generation sequencing panel
Federica Buonocore (London)
   
16:30OC3.2Glucocorticoids stabilise the microtubule network to inhibit cell migration
Stephen Kershaw (Manchester)
   
16:45OC3.311β-HSD1-mediated decrease in COX-2 expression is abrogated by hypoxia in human dermal fibroblasts
Ana Tiganescu (Leeds)
   
17:00OC3.4Urine steroid metabolomics as a novel diagnostic tool for early detection of recurrence in adrenocortical carcinoma
Vasileios Chortis (Birmingham)
   
17:15OC3.5Glucocorticoid pattern-dependent gene regulation in the rat hippocampus
Becky Conway-Campbell (Bristol)
   
17:30OC3.6Female 5β-reductase knockout mice are protected from diet induced obesity, insulin resistance and glucose intolerance
Laura Gathercole (Oxford)
   
16:15 17:45  Oral Communications 4: Diabetes and cardiometabolic complications
Six oral communications from selected abstracts submitted by delegates
Fintry
Chairs: Terence Pang (Dudley) & Jonathan Hazlehurst (Oxford)
16:15OC4.1Acute intense exercise restores defective counter-regulation in Type 1 Diabetes through a process of dis-habituation
Alison McNeilly (Dundee)
   
16:30OC4.2Thermal imaging as a novel non-invasive method to measure human brown adipose tissue activity in humans
Victoria Salem (London)
   
16:45OC4.35α-Tetrahydrocorticosterone exhibits topical anti-inflammatory action with limited adverse effects on angiogenesis
Annalisa Gastaldello (Edinburgh)
   
17:00OC4.4Hyperinsulinaemia due to inhibition of 5α-reductases is ameliorated by liver-selective glucocorticoid receptor antagonism in diet-induced obesity
Tracy Mak (Edinburgh)
   
17:15OC4.5Glucagon Increases Energy Expenditure Independently of Brown Adipose Tissue Activation in Humans
Chioma Izzi-Engbeaya (London)
   
17:30OC4.6Cardiac fibrosis and the balance between glucocorticoid and mineralocorticoid receptor signalling
Rachel Richardson (Newcastle upon Tyne)
   
16:15 17:45  Symposium 9: The endocrinology of the thin
Mechanisms and therapies at unhealthily low body mass states
Supported by Endocrine Connections
Moorfoot & Kilsyth
Chairs: Daniel Morganstein (London) & Clare McFadden (Edinburgh)
16:15S9.1Endocrine dysfunction in anorexia nervosa
Karen Miller (Boston, MA, USA)
   
16:45S9.2Paradoxical metabolism neutralizes immunity in cachexia
Thomas Flint (Cambridge)
   
17:15S9.3Ghrelin in frailty
Anne Cappola (Philadelphia, PA, USA)
   
16:15 17:45  Clinical Management Workshop 3: Biological therapies - cause and cure of endocrine diseases
Immunotherapy for the clinical endocrinologist
Main Hall, Pentland
Chairs: Paul Newey (Dundee) & Anna Mitchell (Newcastle upon Tyne)
16:15CMW3.1The thyroid and rituximab
Mario Salvi (Milan, Italy)
   
16:45CMW3.2Endocrine sequelae of biological therapies
Carla Moran (Cambridge)
   
17:15CMW3.3Biological agents in pancreatic neuroendocrine tumours
Christina Thirlwell (London)
   
18:00 18:30  Plenary Lecture 6: Clinical Endocrinology Trust Lecture
Main Hall, Pentland
Chair: Steve Ball (Manchester)
18:00PL6Mining the steroid metabolome in adrenal hormone excess
Wiebke Arlt (Birmingham)
   
18:30 19:00  Plenary Lecture 7: Clinical Endocrinology Trust Visiting Professor Lecture
Main Hall, Pentland
Chair: John Connell (Dundee)
18:30PL7The expanding universe of mineralocorticoids in hypertension
Richard Auchus (Ann Arbor, MI, USA)
   
19:30   Conference Dinner
Ticketed event
The Hub, Edinburgh
Wednesday 4 November 2015
07:30   Registration
Strathblane Hall
07:30 08:30  Breakfast
Tea, coffee and pastries available
Main Hall, Foyer
08:30 09:15  Society for Endocrinology AGM
Main Hall, Pentland
09:15 10:45  Clinical Management Workshop 4: How do I do it? (II)
Clinical tips from the experts
Supported by Clinical Endocrinology and Endocrinology, Diabetes & Metabolism Case Reports
Main Hall, Pentland
Chairs: Colin Johnston (London) & Helen Simpson (Cambridge)
09:15CMW4.1How do I prep a thyrotoxic patient for urgent surgery?
Amit Allahabadia (Sheffield)
   
09:30CMW4.2How do I manage refractory hypocalcaemia
Peter Selby (Manchester)
   
09:45CMW4.3How far do I investigate chronic fatigue?
Annice Mukherjee (Manchester)
   
10:00CMW4.4How do I manage hirsutism?
Thomas Barber (Warwick)
   
10:15CMW4.5How do I manage hormone replacement in teenagers/young adults with learning difficulties?
Helen Spoudeas (London)
   
10:30CMW4.6How do I manage men who have used anabolic steroids?
Andrew Toogood (Birmingham)
   
09:15 10:45  Applied Physiology Workshop 1: Evolving model systems for complex tissues
From cells to organs in the lab
Sidlaw
Chairs: Kevin Docherty (Aberdeen) & Shareen Forbes (Edinburgh)
09:15APW1.1Modelling human diseases with stem cell derived hypothalamic neurones
Florian Merkle (Cambridge)
   
09:45APW1.2Regeneration in the hypothalamus
Marysia Placzek (Sheffield)
   
10:15APW1.3Cell replacement and regeneration of beta cells as novel therapy for diabetes
Neil Hanley (Manchester)
   
09:15 10:45  Symposium 10: Blood and guts: how the intestine transduces nutritional cues to endocrine signals
How does food talk to the gut?
Supported by Journal of Endocrinology
Moorfoot & Kilsyth
Chairs: Robert Semple (Cambridge) & Ben Challis (Cambridge)
09:15S10.1Incretin hormones as regulators of appetite: from concept to clinical use
John Wilding (Liverpool)
   
09:45S10.2Gut lipid sensing and energy homeostasis
Frank Duca (Toronto, Canada)
   
10:15S10.3Short chain fatty acids in the regulation of energy homeostasis
Gary Frost (London)
   
11:00 11:30  Plenary Lecture 8: Society for Endocrinology European Medal Lecture
Main Hall, Pentland
Chair: Karen Chapman (Edinburgh)
11:00PL8Repositioning of the mineralocorticoid receptor antagonists: pathophysiological basis and therapeutic issues 
Frederic Jaisser (Paris, France)
   
11:30 12:00  Tea & coffee
Exhibition Hall, Lennox Suite
12:00 13:30  Oral communications 5: Thyroid and parathyroid
Six oral communications from selected abstracts submitted by delegates
Sidlaw
Chairs: Duncan Bassett (London) & Peter Taylor (Cardiff)
12:00OC5.1Functional consequences of germline mutations in a novel non-RET medullary thyroid cancer susceptibility gene
Martin Read (Birmingham)
   
12:15OC5.2A novel, missense, mutation (P81R) in the thyrotropin-releasing hormone receptor gene in congenital central hypothyroidism
Olympia Koulouri (Cambridge)
   
12:30OC5.3Use of 11-C-Methionine PET to loacliase parathyroid adenoma/hyperplasia-a single centre experience
Ben Challis (Cambridge)
   
12:45OC5.4A novel modulator of cellular invasion and metastasis in endocrine cancer
Waraporn Imruetaicharoenchoke (Birmingham)
   
13:00OC5.5Investigating the genetic architecture of gland-in-situ congenital hypothyroidism by comprehensive screening of eight known causative genes
Nadia Schoenmakers (Cambridge)
   
13:15OC5.6Safety review of liothyronine use: a 20 year observational follow up study
Graham Leese (Dundee)
   
12:00 13:30  Oral communications 6: Advances in reproduction and signalling
Six oral communications from selected abstracts submitted by delegates
Moorfoot & Kilsyth
Chairs: Ruth Andrew (Edinburgh) & Konstantinos Manolopoulos (Birmingham)
12:00OC6.1Neurokinin B receptor antagonist limits kisspeptin-10 induced LH secretion in women
Karolina Skorupskaite (Edinburgh)
   
12:15OC6.2Kisspeptin-54 safely and effectively triggers oocyte maturation during IVF treatment in women at high risk of developing ovarian hyperstimulation syndrome (OHSS)
Ali Abbara (London)
   
12:30OC6.3Mutations in HS6ST1 are causal in self-limited delayed puberty, as well as idiopathic hypogonadotropic hypogonadism
Sasha Howard (London)
   
12:45OC6.4Calcium-sensing receptor internalisation is impaired in cells expressing FHH3-associated AP2σ mutations
Caroline Gorvin (Oxford)
   
13:00OC6.5Pituitary tumor transforming gene binding factor (PBF): a novel modulator of iodide uptake and target for Src phosphorylation in breast cancer
Vikki Poole (Birmingham)
   
13:15OC6.6Glucocorticoids induce rapid and persistent chromatin remodelling at a glucocorticoid receptor bound locus in macrophages
Alasdair Jubb (Edinburgh)
   
12:00 13:30  Symposium 11: Epigenetics in endocrine-related cancers
Evolving manifestations of epigenetic signalling and nuclear hormone receptors in breast, prostate and ovarian tumourigenesis
Supported by Endocrine-Related Cancer
Fintry
Chairs: Simon Langdon (Edinburgh) & James Thorne (Leeds)
12:00S11.1Oestrogen receptors and epigenetics in breast cancer aetiology and outcome
Simak Ali (London)
   
12:30S11.2Regulation of androgen receptor function in prostate cancer
Moray Campbell (Buffalo, NY, USA)
   
13:00S11.3Epigenetic signalling and acquired drug resistance in ovarian cancer
Robert Brown (London)
   
12:00 13:30  Symposium 12: Corticosteroids - getting to the heart of the matter
This symposium will address the role of corticosteroids and therapeutic approaches in cardiovascular disease and the potential for cardio-selective therapeutic interventions
Supported by Journal of Molecular Endocrinology
Main Hall, Pentland
Chairs: Frederic Jaisser (Paric France) & Rachel Richardson (Edinburgh)
12:00S12.1Glucocorticoids and the control of cardiac function
Gillian Gray (Edinburgh)
   
12:30S12.2Selective targeting of the mineralocorticoid receptors (MR) and cardiovascular disease
Morag Young (Clayton, Australia)
   
13:00S12.3MR antagonists - lessons from clinical trials
Faiez Zannad (Nancy, France)
   
12:00 13:30  Senior Endocrinologists Session
Tinto
Chairs: Paul Belchetz (Leeds) & Ian Mason (Edinburgh)
12:00SE1.1The new tachykinin, endokinin: its role in emesis, sialorrhea and smoking in pregnancy
Phil Lowry (Reading)
   
12:18SE1.2What is visual art, why is it made, and for whom?
Paul Beltchetz (Leeds)
   
12:36SE1.3Steroid mass spectrometry: a 50 year history
Cedric Shackleton (Oakland, CA, USA)
   
12:54SE1.4A crackpot ejection theory about China's unique natural glass
David Anderson (Rome, Italy)
   
13:12SE1.5Understanding the biochemistry underpinning hypoglycaemia of the Insulin Autoimmune Syndrome (IAS) is paramount for diagnosis and management
Adel Ismail (Wakefield)
   
13:30 14:45  Lunch & poster viewing
Exhibition Hall, Lennox Suite
13:30 14:45  Internis Satellite
Fintry
13:45 14:45  Shire Satellite: Understanding adrenal insufficiency (AI): from disease burden to treatment evaluation
Sidlaw
Chair: Ashley Grossman (Oxford)
Assessing disease burden in AI: data from the real world
Robert Murray (Leeds)
   
Treatment and management of AI: insights from a German cohort
Marcus Quinkler (Berlin, Germany)
   
The economics of orphan drugs
Leela Barham (Royston)
   
14:45 15:30  Meet the Expert 7: Designer Receptors Exclusively Activated by Designer Drugs (DREADD) - Novel pharmacological handles on the endocrine system
Supported by Clinical Endocrinology
Sidlaw
Chair: Lora Heisler (Aberdeen)
14:45MTE7Designer receptors Exclusively Activated by Designer Drugs (DREADD) - Novel pharmacological handles on the endocrine system
Alastair Garfield (Edinburgh)
   
14:45 15:30  Meet the Expert 8: Updated thyroid cancer guidelines
Supported by Clinical Endocrinology
Moorfoot & Kilsyth
Chair: Graham Williams (London)
14:45MTE8Updated thyroid cancer guidelines
Petros Perros (Newcastle upon Tyne)
   
14:45 15:30  Meet the Expert 9: Endocrine and non-endocrine aspects of hypothalamic syndromes
Supported by Clinical Endocrinology
Fintry
Chair: Guftar Shaikh (Glasgow)
14:45MTE9Endocrine and non-endocrine aspects of hypothalamic syndromes
Ashley Grossman (Oxford)
   
14:45 15:30  Meet the Expert 10: Diagnosis and management of SIADH
Supported by Clinical Endocrinology
Main Hall, Pentland
Chair: Maralyn Druce (London)
14:45MTE10Diagnosis and management of SIADH
Christopher Thompson (Dublin, Republic of Ireland)
   
15:45 16:15  A year in...Type 2 diabetes
Big breakthroughs over the previous 12 months in the field of Type 2 diabetes research
Main Hall, Pentland
Chair: Chris McCabe (Birmingham)
15:45AYI1A year in...Type 2 diabetes
Nick Wareham (Cambridge)
   
16:15 16:45  Plenary Lecture 9: Society for Endocrinology International Medal Lecture
Main Hall, Pentland
Chair: Steve O'Rahilly (Cambridge)
16:15PL9Controlling the freedom of steroids in health and disease
Geoffrey Hammond (Vancouver, Canada)
   
16:45 17:15  Awards Ceremony
Main Hall, Pentland
17:15 17:30  Closing Remarks
Main Hall, Pentland