Wang et al. describe a preclinical model of polycystic ovary syndrome (PCOS) developed using prenatally androgenised sheep. This model has been found to have dysfunctional subcutaneous adipose tissue, with reduced adipogenesis in adolescence and enlarged adipocytes with increased inflammation in adulthood. Ingenuity pathway analysis highlighted upregulation of fibrotic pathways in the subcutaneous adipose tissue of prenatally androgenised sheep.

The authors conclude that a fibrotic barrier to healthy adipocyte expansion may have a mechanistic role in the development of inflammation in PCOS, offering valuable insights into dysregulation in PCOS.

Read the full article in Journal of Molecular Endocrinology https://doi.org/10.1530/JME-25-0106