Society for Endocrinology - a world-leading authority on hormones

Founding Group

This event has been devised by a Founding Group of experts, who are shaping clinical best-practice in Endocrine Metabolic GPCRs.

 

Davide Calebiro

Davide Calebiro is a Professor of Molecular Endocrinology and Wellcome Trust Senior Research Fellow at the Institute of Metabolism and Systems Research (IMSR) of the University of Birmingham and Co-Director of the Centre of Membrane Proteins and Receptors (COMPARE) of the Universities of Birmingham and Nottingham. He studied Medicine in Milan and Stockholm and obtained a PhD in Molecular Medicine and a Clinical Specialisation in Endocrinology and Metabolic Disease from the University of Milan.

Caroline Gorvin

Caroline Gorvin is a Wellcome Trust & Royal Society Sir Henry Dale Fellow at the Institute of Metabolism and Systems Research, University of Birmingham. She obtained her PhD in 2012 from the University of Oxford, where her research focussed on the cellular mechanisms by which mutations in a chloride-proton antiporter cause the renal disorder Dent’s disease. Caroline continued in Oxford undertaking postdoctoral research investigating the signalling and trafficking of the G protein-coupled receptor (GPCR), calcium-sensing receptor, and its role in calcium homeostasis. Caroline moved to the University of Birmingham in 2018 to establish her research group investigating metabolic GPCRs. Her current research focusses on how metabolic GPCRs cross-talk and interact to regulate appetite and bone metabolism.

Aylin Hanyaloglu

Prof. Aylin Hanyaloglu has been a Principal Investigator at Imperial College London since 2007. She received her BSc in Human Biology from King’s College London in 1997, and while her Ph.D. commenced at the MRC Human Reproductive Sciences Centre, Edinburgh, a move to Perth, Australia, resulted in her Ph.D. in Molecular Endocrinology being awarded in 2002 with Distinction from the University of Western Australia. Prof. Hanyaloglu undertook her postdoctoral training at the University of California, San Francisco, with Professor Mark von Zastrow, where she identified novel core cellular machinery critical for G protein-coupled receptor trafficking and signalling.

Her research focuses on understanding the fundamental cell biological mechanisms regulating GPCR activity, including spatial control of GPCR signalling and receptor crosstalk, and applying these mechanisms for distinct GPCRs with particular focus on women's health, pregnancy, and nutrient sensing in the gut. Her work is currently funded by Biotechnology and Biological Sciences Research Council (BBSRC), Diabetes UK, Wellcome Trust, and the Medical Research Council.

Peter McCormick

Peter McCormick has a degree in Chemistry from Washington University in St. Louis, USA and a PhD in Biochemistry and Biophysics from Texas A&M University, USA. His lab studies the molecular underpinnings of diseases. Their focus is on the role of the super family of G-protein coupled receptors (GPCR) in these mechanisms. His work in GPCRs has been published in Science, PNAS, PLoS Biology, Molecular Psychiatry, JBC, JNCI, BMC Biology, Molecular Pharmacology, eLife, and the Journal of Neuroscience. He has worked with GSK, Sosei-Heptares, Neurolixis and sits on the scientific advisory board of CrystalBio (Shenzhen) and Cumulus Oncology (UK).

He is currently the associate pro-vice chancellor for International Partnerships and Postgraduate Affairs and Chair in Pharmacology at the University of Liverpool.

Aaron Novikoff

Aaron Novikoff is a tenured postdoctoral researcher at Helmholtz Munich – Institute for Diabetes and Obesity. He earned his PhD in 2022 at Helmholtz Munich, where he investigated the molecular pharmacology of novel incretin receptor dual- and triple-agonists, as well as nuclear hormone-conjugated GLP-1 agonists, under the mentorship of Prof. Timo Müller and Prof. Matthias Tschöp. As a Helmholtz High Potential Fellow, his current research centers on novel peptide-based drug design, with an emphasis on harnessing subcellular dynamics and polypharmacology to enhance systemic therapeutic outcomes against diabetes and obesity.

Alejandra Tomas-Catala

Alejandra Tomas is a molecular cell biologist and Senior Lecturer at the Department of Metabolism, Digestion and Reproduction, Imperial College London. She obtained a PhD in Biochemistry from University College London and spent several years in Switzerland working on the study of membrane trafficking processes in pancreatic beta cells, before returning to the UK, first to her Department at UCL, and then to lead a laboratory at Imperial following the receipt of an MRC New Investigator Award in 2015.

Her most significant research outputs include the identification of the main incretin receptor trafficking regulators in beta cells, the characterisation of biased GLP-1R agonists with improved therapeutic profiles, and the study of the influence of the lipid microenvironment on the regulation of incretin receptor outputs, with papers in high-impact journals such as PLoS Biology, Nature Communications, Diabetes and Science Advances. She has recently joined the Society for Endocrinology Metabolic and Obesity Network group to serve as scientific advisor in these areas.