Via www.jobs.ac.uk. This 4 year PhD is based at the Institute of Cellular Medicine, Newcastle University. Alternative pre-mRNA splicing plays an important role in reproductive biology and development. Alternative splicing events also have the potential to both cause and effect tumour progression. The proposed project will investigate the factors and mechanisms that effect co-transcriptional and splicing decisions of nuclear hormone receptors in different cell types. The student will explore the role of specfic DNA- and RNA- binding proteins by combining techniques including Ch-IP (Chromatin Immuno-Precipitations) and CLIP (Cross Linking Immuno- Precipitation), respectively. As part of the research training for this project, you will undertake the MRes in Medical and Molecular Biosciences. Applicants should hold, or expect to obtain, a first-class or upper-second-class Honours degree in any area of biological science. The award covers fees and a stipend starting at £12,940 per annum. To apply, complete the University's postgraduate application form at the link below, quoting reference number SAR27. The closing date is 24 June 2008. For further information, please contact Dr Alison Tyson-Capper: [email protected] or Dr David Elliott, [email protected].

Application form