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16 Mar 2019


Strength training may reduce the risk of diabetes in obesity


Strength training over a short time period can reduce fat stores in the liver and improve blood glucose control in obese mice, according to a study published in the Journal of Endocrinology. The study reports that strength training over a short time-period, less than would be enough to change body fat composition in humans, was sufficient to reduce the accumulation of liver fat and improve regulation of blood glucose in obese mice, even without overall loss of body weight. These findings suggest that strength training may be a fast and effective strategy for reducing the risk of fatty liver disease and diabetes in obese people.

Obesity is a growing, global health epidemic that needs more effective intervention strategies to avoid debilitating complications including fatty liver disease and diabetes. Approximately 94% of obese people are diagnosed with non-alcoholic fatty liver disease, which leads to inflammation in this vital organ and impairs its ability to regulate blood glucose. This increases the risk of type 2 diabetes and its associated serious complications, including nerve and kidney damage. Although increased physical activity is a widely accepted method of improving health and aiding weight loss, the relative benefits of different types, durations and intensities of physical activities are still under much debate. A wealth of research has focussed on the benefits of energy-burning aerobic exercise, with the potential benefits of muscle-building strength and resistance training often neglected.

In this study, Leandro Pereira de Moura and colleagues at the School of Applied Sciences at the University of Campinas in Brazil, investigated the effects of strength-based exercise on liver fat accumulation, blood glucose regulation and markers of inflammation in obese mice. Obese mice performed strength training over a short time-period, the equivalent of which in humans would not be enough to change their body fat composition. After this short-term training the mice had less fatty livers, reduced levels of inflammatory markers and their blood glucose regulation was improved, despite no change in their overall body weight.

Dr Pereira de Moura comments, “The fact that these improvements in metabolism occurred over a short time, even though the overall amount of body fat was unchanged, suggest that strength training can have positive effects on health and directly affect liver function and metabolism. so may be a more effective, non-drug and low-cost strategy for improving health in obesity.”

Dr Pereira de Moura cautions: “Although these findings show a clear benefit in obese mice, to mimic strength training in animals is difficult. More investigation is required in both animals and people to really understand how liver metabolism is affected by strength training. It should be noted that these health benefits would be even more effective if accompanied by reduction of body fat. However, based on these findings obese individuals could be directed to increase their activity through strength training but they should always first consult their primary care physician.”

Dr Pereira de Moura and colleagues now plan to investigate the mechanisms underlying these findings, to identify how they may be maximised and to help devise real guidance for obese individuals. They are currently conducting studies that examine the impact of different exercise protocols, such as aerobic exercise or aerobic exercise combined with strength training, on fatty liver accumulation. It is possible that by better understanding how strength training improves liver function, new targets for drug intervention that may prevent or reduce the risk of fatty liver disease and type 2 diabetes in obesity may be identified.

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The study “Short-term strength training reduces gluconeogenesis and NAFLD in obese mice” was published in the Journal of Endocrinology on Saturday 16 March 2019.

The Journal of Endocrinology is published by Bioscientifica, an innovative and agile publisher. Bioscientifica collaborates with learned societies worldwide to develop new and existing quality products that meet the ever-changing needs of the biomedical community. Our publishing portfolio includes journals and online resources, including Journal of Molecular Endocrinology, Endocrine-Related Cancer, Endocrine Connections, Bone Abstracts and Endocrinology, Diabetes & Metabolism Case Reports. Bioscientifica is a wholly-owned commercial subsidiary of the Society for Endocrinology.

The Society for Endocrinology is a UK-based membership organisation representing a global community of scientists, clinicians and nurses who work with hormones. Together we aim to improve public health by advancing endocrine education and research, and engaging wider audiences with the science of hormones. www.endocrinology.org

 

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